Systolic Pressure Intervention Trial Factors Affecting Factors Affecting Atherosclerosis Study
- Conditions
- HypertensionChronic Kidney Disease
- Registration Number
- NCT01475747
- Lead Sponsor
- University of Utah
- Brief Summary
Systolic Pressure Intervention Trial (SPRINT) is a large scale randomized trial of \~ 9250 adults aged 50 years or older with high cardiovascular risk sponsored by NIH. The study is designed to recruit 45% of the study population with Chronic Kidney Disease (CKD). The trial will test the effects of low systolic blood pressure (SBP) goal of \< 120 mm Hg versus the standard goal of \< 140 mm Hg on the primary composite of cardiovascular events and death. One of the pre-specified secondary outcome is the progression of kidney disease. In this ancillary named SPRINT - Factors affecting Atherosclerosis STudy (FAST), the investigators plan to take advantage of the unique opportunities afforded by the parent study to examine issues that are of significant public health importance.
This is an observational study in SPRINT participants. This study will examine mechanistically, the factors affecting the progression of atherosclerosis in CKD.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 595
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Development Rate of Atherosclerosis Baseline and 30 months Correlation of the presence of CKD and rate of progression of atherosclerosis as assessed by magnetic resonance imaging (MRI) of the carotid artery.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (12)
Stanford University
🇺🇸Palo Alto, California, United States
Mayo Clinic Jacksonville
🇺🇸Jacksonville, Florida, United States
University of Colorado Denver
🇺🇸Denver, Colorado, United States
University of Pennsylvania
🇺🇸Pittsburgh, Pennsylvania, United States
University of Pittsburg
🇺🇸Pittsburgh, Pennsylvania, United States
George Washington University
🇺🇸Washington, District of Columbia, United States
University of Minnesota
🇺🇸Minneapolis, Minnesota, United States
Wake Forest University
🇺🇸Winston-Salem, North Carolina, United States
Case Western Reserve University
🇺🇸Cleveland, Ohio, United States
University of Washington
🇺🇸Seattle, Washington, United States
Cleveland Clinic
🇺🇸Cleveland, Ohio, United States
University of Utah
🇺🇸Salt Lake City, Utah, United States