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Respiratory Mechanics and Metabolic Changes During Low Pressure Laparoscopic Cholecystectomy

Phase 2
Completed
Conditions
Laparoscopic Cholecystectomy
Interventions
Registration Number
NCT02469831
Lead Sponsor
Assiut University
Brief Summary

The investigators aim to investigate the differences between deep continuous muscle relaxation and moderate blockade during low-pressure (8 mmHg) laparoscopic cholecystectomy in respect to metabolic changes and respiratory mechanics.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
40
Inclusion Criteria
  • more than 18 years
  • undergoing elective laparoscopic cholecystectomy
Exclusion Criteria
  • previous surgeries,
  • a history of venous or arterial diseases,
  • BMI (≥30 kg/m2),
  • Allergy to rocuronium.
  • Significant liver dysfunction.
  • Significant renal dysfunction (S-creatinine > 200 umol/l).
  • Neuromuscular disease that might impair neuromuscular blockade
  • Pregnant or breastfeeding.
  • Indication for rapid sequence induction.
  • Inability to informed consent

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
group DRocuroniumdeep neuromuscular block by rocuronium defined :post tetanic (PTC) \>1 but no response to a train of four (TOF) stimulation.
group IRocuroniumintermediate neuromuscular block by rocuronium defined as TOF count of 1-3.
Primary Outcome Measures
NameTimeMethod
respiratory mechanics (Dynamic compliance)intraoperative

Dynamic compliance

Secondary Outcome Measures
NameTimeMethod
surgeon satisfaction (scale from 1 to 5)intraoperative

scale from 1 to 5

postoperative nausea and vomitingpostoperative for 6 hours
metabolic changes (blood lactate)intraoperative

blood lactate

postoperative pain (VAS score)postoperative for 6 hours

VAS score

completion of surgical procedureintraoperative

yes or no

Trial Locations

Locations (1)

Al Rajhy liver hospital

🇪🇬

Assuit, اسيوط, Egypt

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