Evaluation of an Anti-Shivering Protocol for Targeted Temperature Management Following Cardiac Arrest
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 165
- 试验地点
- 1
- 主要终点
- NMB usage
研究概览
简要总结
This will be a single center, retrospective, before-and-after, chart review of all patients undergoing TTM between June 1, 2017 and May 31, 2021 at MDMC. Initiation of the new TTM protocol occurred on April 22, 2019.
详细描述
This will be a single center, retrospective, before-and-after, chart review of all patients undergoing TTM between June 1, 2017 and May 31, 2021 at MDMC. Initiation of the new TTM protocol occurred on April 22, 2019. To allow for an adequate washout period, patients who were initiated on TTM before April 22, 2019 will be in the "before" group and patients initiated on TTM on or after June 1, 2019 will be in the "after" group. Patients will be identified based on electronic medical records search of order sets utilized in TTM and confirmed with manual chart review. Statistical analysis will be performed as detailed below.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age > 18 years
- •Diagnosis of cardiac arrest
- •Initiation of TTM via Arctic Sun® device
排除标准
- •Initiation of TTM > 12 hours after cardiac arrest
- •Receiving NMBs for an indication other than TTM
- •Early termination of TTM (less than 24 hours)
结局指标
主要结局
NMB usage
时间窗: June 1, 2017 - May 31, 2021
vecuronium or cisatracurium
次要结局
- ICU length of stay(June 1, 2017 - May 31, 2021)
- Time to target temperature from initiation of TTM(June 1, 2017 - May 31, 2021)
- NMB usage(June 1, 2017 - May 31, 2021)
- Patients discharged home(June 1, 2017 - May 31, 2021)
- Patients with a breakthrough fever (temperature > 38°C) in the first 72 hours of TTM initiation(First 72 hours of TTM initiation)
- Proportion of patients cooled to 33°C versus 36°C(June 1, 2017 - May 31, 2021)