A New Surgical Strategy to Protect the Inferior Parathyroid

Not Applicable

Not yet recruiting

• Conditions: Thyroid Cancer
• Interventions: Procedure: Resection based on "thymus-vascular-inferior parathyroid" complex

• Registration Number: NCT05758025
• Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Brief Summary

The incidence of temporary hypoparathyroidism after thyroid surgery is 14%-60%, and the incidence of permanent hypoparathyroidism is 4%-11%. The protection of parathyroids has always been the focus and difficulty of thyroid surgery. The anatomical position of the superior parathyroids is relatively fixed, and can be preserved in situ easily; while the anatomical position of inferior parathyroids varies greatly between patients. It is always difficult to look for, identify, and protect them. Concepts such as thyro-thymic ligament and "thymus-vascular-inferior parathyroid plane" were raised to help identify the inferior parathyroids. We found that this surgical strategy can protect inferior parathyroids in situ effectively in our retrospective studies. Thus, we are going to carry out a prospective study to compare the new method and the traditional method of thyroidectomy, to see if more inferior parathyroids can be protected in situ through the new surgical strategy.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-02
• Study First Submitted: 2023-02-24
• Study First Submitted QC: 2023-02-24
• Last Update Submitted: 2023-02-24
• Study Start: 2023-03-01
• Study First Posted: 2023-03-07
• Last Update Posted: 2023-03-07
• Primary Completion: 2024-03-01
• Study Completion: 2024-06-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 506

Inclusion Criteria

• initial thyroid surgery; thyroidectomy with/without central lymph node dissection

Exclusion Criteria

• coexisting parathyroid disease; need lateral neck dissection; history of radio-iodine ablation treatment

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Resection based on "thymus-vascular-inferior parathyroid" complex	Resection based on "thymus-vascular-inferior parathyroid" complex	-

Primary Outcome Measures

Name	Time	Method
Primary outcome	Postoperative day 1	the incidence of hypothyroidism

Secondary Outcome Measures

Name	Time	Method
Secondary outcome	Postoperative day 1	the incidence of parathyroid hormone reduced greater than 50% than parathyroid hormone level before surgery

Trial Locations

Locations (1)

Second Affiliated Hospital Zhejiang University School of Medicine; 🇨🇳 Hangzhou, Zhejiang, China