NL-OMON55402已完成3 期
Randomized controlled trial on clinical outcomes and safety of Instant MSC Product accompanying Autologous Chondron Transplantation (IMPACT) for focal articular cartilage lesions of the knee - IMPACT2
niversitair Medisch Centrum Utrecht0 个研究点目标入组 60 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 60
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- Provides written informed consent, is able to understand the content of the
- •study, understands the requirements for follow-up visits and is willing to
- •provide the required information at follow-up visits and in the questionnaires.
- •- Symptomatic articular cartilage lesion of the knee (femoral condyles or
- •- Age 18 to 45 years old
- •- Modified Outerbridge Grade III or IV isolated cartilage lesion of the knee.
- •- A post-debridement size of the cartilage lesion > 2cm2 and <= 8 cm2
- •- At least 50% of functional meniscus remaining. Meniscal repair or resection
- •is allowed during the IMPACT surgery provided that the surgeon is able to
- •confirm that at least 50% of functional meniscus remains.
- •- Stable knee ligaments (i.e. anterior and posterior cruciate ligaments).
排除标准
- •- Malalignment of >5 degrees
- •- (History of) osteoarthritis, defined as Kellgren-Lawrence grade >3 as
- •determined from appropriate X-ray.
- •- Concomitant inflammatory disease that affects the joint (rheumatoid
- •arthritis, metabolic bone disease, psoriasis, gout, symptomatic
- •chondrocalcinosis)
- •- (History of) Septic arthritis.
- •- (History of) Total menisectomy in the target knee joint.
- •- Any surgery in the knee joint for cartilage treatment, 6 months prior to
- •study inclusion.
- •- Risk groups for MRI scanning due to the magnetic field like patients with
- •pacemakers, nerve stimulators, metal particles, stents, clips or implants,
- •(possible) pregnancy or breast feeding.
研究者
相似试验
进行中（未招募）
1 期
Study on the IMPACT-treatment of cartilage defects (local damage to the cartilage) of the knee. In this treatment cells are obtained from the cartilage defect (from the damaged cartilage) and mixed with stromal cells from a donor. These cells are obtained and placed back in the defect during a single surgery. The primary goal of this study is to determine the effect of the IMPACT-treatment on pain and function of the knee.Cartilage defect of the femoral condyle or trochleaEUCTR2018-003470-27-NLMC Utrecht60
招募中
不适用
Randomized Controlled Trial on Clinical Outcomes of EUS-guided Biliary Drainage vs. Balloon-enteroscopy-assisted ERCP for Malignant Biliary ObstructioBiliary obstructionJPRN-UMIN000038316Sendai City Medical Center40
招募中
不适用
Randomized controlled trial about the clinical outcome between Carotid Wallstent and Precise stent in Carotid Artery Stentinginternal carotid artery stenosisJPRN-UMIN000008533Wakayama Rosai Hospital Medical Research Center200
尚未招募
Unknown
To study the efficacy of vachadi bidalaka in the management of krimigranthi w. s.r to ulcerative blepharitisCTRI/2024/06/068293Sangam sevabhavi trust ayurved mahavidyalaya graduate and research centre sangamner
招募中
3 期
To evaluate effect of munditika churna and Haritaki churna in the management of Vatarakta (gout)CTRI/2023/09/057542Pathan Md Junaid Naim Khan