Cardiotoxicity of Aluminum Phosphide Poisoning; Tropinin and CKmb as Early Biomarkers
- Conditions
- CardiotoxicityAluminum Phosphid Poisoning
- Registration Number
- NCT04191265
- Lead Sponsor
- Assiut University
- Brief Summary
Aluminum phosphide (AlP) or rice tablet is a cheap pesticide. When it comes in contact with acid (gastric acid) or moisture, it releases phosphine (PH3) gas. The heart,lungs, liver are the main targets in acute Aluminum phosphide (AlP) poisoning. Most deaths occur due to cardiovascular toxicity.
- Detailed Description
Aluminium phosphide is a potent respiratory chain enzyme inhibitor. Its most important effect is the inhibition of cytochrome c oxidase. The inhibition of cytochrome c oxidase and other enzymes leads to the generation of superoxide radicals and cellular peroxides , and subsequent cellular injury through lipid peroxidation and other oxidant mechanisms. It stimulates the production of hydrogen peroxide and reactive oxygen species, malonyldialdehyde (MAD), increases superoxide dismutase and inhibits catalase, peroxidase and glutathione . Oxidative stress is one of the main mechanisms of action of aluminium phosphide toxicity
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 60
ALP poisoned cases
- admitted with free ECG
concomitant ingesion of other drugs or toxins
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method assess serum tropinin and CKmb as biomarkers for early detection of ALP induced myocardial injury 6 months assess serum tropinin and CKmb as biomarkers for early detection of ALP induced myocardial injury
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Doaa
🇪🇬Assiut, Egypt