Effect of oxygen on management of patients having brain surgery

Completed

• Conditions: Other and unspecified cord compression,

• Registration Number: CTRI/2017/11/010499
• Lead Sponsor: Dr Hemangi S karnik

Brief Summary

End tidal CO2 values are routinely used to monitor adequacy of ventilation.In neuroanaesthesia practice, continuous assessment of ventilation and control of PaCO2 is essential for adjusting intracranial pressure as well as cerebral perfusion.

The value of EtCO2 depends on extra pulmonary and pulmonary factors.In baseline conditions,the gradient between PaCO2 and EtCO2 range between 3-5 mmHg.Determinants of this gradient are multifactorial and magnitude of their effect is often unpredictable.Larson and Severinghans reported that the administration of O2 to awake sitting subjects led to an increase in PaCO2-EtCO2 gradient.They attributed this finding to the vasodilatory effect of O2 on blood vessels at the base of lung.

The current study was undertaken to assess the effect of varying levels of inspired oxygen fraction on difference between arterial carbon dioxide levels and exhaled CO2 levels in patients undergoing neurosurgery.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-01-27
• Study Completion: 2017-08-31
• Last Update Posted: 2018-12-14

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• 1. Patients undergoing neurosurgical procedures in supine or supine with head up position.
• 2. Patients needing invasive arterial access during surgery.

Exclusion Criteria

• 1. Patients with impaired pulmonary gas exchange (baseline hypercarbia,hypoxia).
• 2. Patients with dependence on oxygen supplementation or CPAP.
• 3. Patients with bronchial asthma/COPD.
• 4. Patients with chest trauma/ chest drain in situ.
• 5. Operated pneumonectomy or lobectomy in past.
• 6. Patients with abdominal distension /pregnancy/ascites/any other cause affecting breathing.
• 7. Any contraindication for nitrous oxide.
• 8. Patients requiring frequent changes in ventilatory strategies.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To ascertain if PaCO2_EtCO2 gradient changes with varying FiO2 concentration.	August 2017

Secondary Outcome Measures

Name	Time	Method
to find correlation between FiO2 % and PaCO2-EtCO2 gradient,if any.	June 2017

Trial Locations

Locations (1)

Lokmanya tilak municipal medical college and hospital; 🇮🇳 Mumbai, MAHARASHTRA, India

Lokmanya tilak municipal medical college and hospital

🇮🇳Mumbai, MAHARASHTRA, India

Neha Magoon

Principal investigator

7045704151

neha_magoon@yahoo.com