“Effect of different inhaled oxygen concentration on PaCO2-EtCO2 gradient in neurosurgical patients. â€
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- To ascertain if PaCO2_EtCO2 gradient changes with varying FiO2 concentration.
研究概览
简要总结
End tidal CO2 values are routinely used to monitor adequacy of ventilation.In neuroanaesthesia practice, continuous assessment of ventilation and control of PaCO2 is essential for adjusting intracranial pressure as well as cerebral perfusion.
The value of EtCO2 depends on extra pulmonary and pulmonary factors.In baseline conditions,the gradient between PaCO2 and EtCO2 range between 3-5 mmHg.Determinants of this gradient are multifactorial and magnitude of their effect is often unpredictable.Larson and Severinghans reported that the administration of O2 to awake sitting subjects led to an increase in PaCO2-EtCO2 gradient.They attributed this finding to the vasodilatory effect of O2 on blood vessels at the base of lung.
The current study was undertaken to assess the effect of varying levels of inspired oxygen fraction on difference between arterial carbon dioxide levels and exhaled CO2 levels in patients undergoing neurosurgery.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients undergoing neurosurgical procedures in supine or supine with head up position.
- •Patients needing invasive arterial access during surgery.
排除标准
- •Patients with impaired pulmonary gas exchange (baseline hypercarbia,hypoxia).
- •Patients with dependence on oxygen supplementation or CPAP.
- •Patients with bronchial asthma/COPD.
- •Patients with chest trauma/ chest drain in situ.
- •Operated pneumonectomy or lobectomy in past.
- •Patients with abdominal distension /pregnancy/ascites/any other cause affecting breathing.
- •Any contraindication for nitrous oxide.
- •Patients requiring frequent changes in ventilatory strategies.
结局指标
主要结局
To ascertain if PaCO2_EtCO2 gradient changes with varying FiO2 concentration.
时间窗: August 2017
次要结局
- to find correlation between FiO2 % and PaCO2-EtCO2 gradient,if any.(June 2017)