The incidence of, and risk factors for liver disorders related to drugs
Recruiting
- Conditions
- Drug Induced Liver InjuryHepatotoxicity10019654
- Registration Number
- NL-OMON33992
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
Patients who present themselves to the GP with clinical symptoms and complaints which could be related to liver damage, and who have at least òr an ALAT value of >2 times the normal value, òr who have a combination of a raised ASAT, alkalic phosfatase, and bilirubin, where at least one of these 3 had to be >2 times the normal value
Exclusion Criteria
cancer/carcinoma, liver injury or another form of hepatitis, cholelithiasis, cholecystitis, acute or chronic pancreatitis, heart failure, alcohol abusus, HIV infection, medical history< 1 yr in IPCI database
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Incidence of drug induced liver disorders in an unselected population in<br /><br>general circumstances.<br /><br>Relative risk of certain liver disorders when using certain medications.<br /><br>Genetic role in hepatotoxicity.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Risk profile of different medications </p><br>