Association of Psychological Distress in Patients With Lung Cancer

Recruiting

• Conditions: Lung Neoplasms; IMMUNOTHERAPY; Targeted Molecular Therapy; Psychological Distress; Prognosis Factors; Lifestyle, Healthy

• Registration Number: NCT06218901
• Lead Sponsor: Shanghai Chest Hospital

Brief Summary

Psychological distress is a multi-factorial experience of a psychological, social, spiritual, and/or physical nature that may interfere with one's ability to cope effectively with cancer, physical symptoms and treatment. Psychological distress is common and affects the efficacy and prognosis of patients with lung cancer. The systematic anti-tumor therapy may effectively relieve psychological distress including anxiety, depression, and fatigue in patients with advanced lung cancer, the relief of the psychological distress can in turn improve the therapeutic effect.

In summary, this study is to explore the associations of (dynamic) psychological stress with the efficacy and survival of anti-tumor therapy including immunotherapy and targeted therapy for advanced lung cancer patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-01-01
• Study First Submitted: 2024-01-12
• Study First Submitted QC: 2024-01-12
• Study First Posted: 2024-01-23
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-20
• Last Update Posted: 2025-05-22
• Primary Completion: 2027-12-31
• Study Completion: 2028-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

• Histologically proven diagnosis of lung cancer
• 18 years of age or older
• Ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria

• Not willing to participate in this clinical trial

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Objective response rate (ORR)	20 years	Collect detailed clinical information on patients with SCLC via the electronic medical records
Disease control rate (DCR)	20 years	Collect detailed clinical information on patients with SCLC via the electronic medical records
Progression-free survival (PFS)	20 years	Collect detailed clinical information on patients with SCLC via the electronic medical records

Secondary Outcome Measures

Name	Time	Method
Overall survival (OS)	20 years	Collect detailed clinical information on patients with SCLC via the electronic medical records

Trial Locations

Locations (1)

Shanghai Chest Hospital; 🇨🇳 Shanghai, Shanghai, China