The role of renal tubular epithelial cells in the progression of chronic kidney disease in Morbus Fabry
- Conditions
- The study aims to investigate subcellular pathomechanisms leading to onset and progression of chronic kidney disease in male patients suffering from Fabry's disease.E75.2N17-N19Other sphingolipidosisRenal failure
- Registration Number
- DRKS00012943
- Lead Sponsor
- niversitätsklinikum Freiburg
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Male
- Target Recruitment
- 20
Inclusion Criteria
Confirmation of Fabry's disease by enzymatic / molecular gentic investigation.
Exclusion Criteria
Kidney disease / potential risk factor suspected to be associated with kidney disease.
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Establishment and characterization of human renal epithelial cell lines derived from male patients suffering from Fabry's disease and healthy controls.
- Secondary Outcome Measures
Name Time Method Differences in mitochondrial energy metabolism and the autophagic pathway in healthy male controls and patients suffering from Fabry's disease.