The Effects of Local Infiltration Versus Epidural Following Liver Resection 2
Not Applicable
Completed
- Conditions
- Open Liver Resection
- Interventions
- Device: EpiduralDevice: Wound catheter
- Registration Number
- NCT01747122
- Lead Sponsor
- University of Edinburgh
- Brief Summary
The investigators plan to compare epidurals versus wound catheters for effects on pain relief and recovery following open liver surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 97
Inclusion Criteria
- Patients undergoing open hepatic resection for benign or malignant conditions.
Exclusion Criteria
- Patients with contraindication to either epidural or wound catheter techniques.
- Inability to give written, informed consent.
- Jaundice (Bilirubin > 100 μmol/L)
- Liver resection combined with secondary surgical procedure.
- Age < 18 years
- Pregnant women
- patients on long term opiates for chronic pain
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Epidural Epidural Standard epidural, pre-operative insertion, to be run for 48 hours Wound catheter Wound catheter Wound catheter
- Primary Outcome Measures
Name Time Method Length of stay Measurement made on day of discharge which is expected to be on average bewteen 5 and 10 days after surgery. Number of days (to nearest half day) patients stay in hospital.
- Secondary Outcome Measures
Name Time Method Central Venous Pressure During liver transection Mean Central Venous Pressure during liver transection will be quantified and compared between groups.
Molecular response to surgery Days 0, 1 and 3 HMGB1, RAGE and cytokines
Operative field asessment During liver transection Estimated Blood Loss Intra-operative Pain Scores Performed daily at 0900 hours. On the day of surgery pain scores will be performed at 2, 6 and 12 hours post surgery. Visual analogue scores of pain experienced.
Pringle time Intra-operative
Trial Locations
- Locations (1)
Royal Infirmary of Edinburgh
🇬🇧Edinburgh, Lothian, United Kingdom