Acute Dietary Nitrate in Dilated Cardiomyopathy
- Conditions
- Cardiomyopathy
- Interventions
- Dietary Supplement: Dietary nitrateDietary Supplement: Placebo
- Registration Number
- NCT02471417
- Lead Sponsor
- Royal College of Surgeons, Ireland
- Brief Summary
Acute consumption of dietary nitrate (as beetroot juice) has been shown to improve exercise capacity in athletes, healthy adults and subjects with both peripheral vascular disease or COPD. Many patients with dilated cardiomyopathy have reduced exercise capacity, The investigators hypothesized that acute nitrate consumption might increase incremental shuttle walk test (ISWT) distance in dilated cardiomyopathy subjects compared to a placebo beetroot juice.
- Detailed Description
Acute consumption of dietary nitrate (as beetroot juice) has been shown to improve exercise capacity in athletes, healthy adults and subjects with both peripheral vascular disease or COPD. Many patients with dilated cardiomyopathy have reduced exercise capacity, The investigators hypothesized that acute nitrate consumption might increase incremental shuttle walk test (ISWT) distance in dilated cardiomyopathy subjects compared to a placebo beetroot juice. This study is a randomized, double-blind placebo-controlled, crossover trial. Resting blood pressure, phlebotomy and ISWT will be performed. Following completion, each subject is randomized to consume beetroot juice or placebo. 3 hours later, the same assessments are repeated by the same people. After a 7d washout, the entire protocol is repeated with the crossover beverage.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Not specified
- Target Recruitment
- 12
- Clinically stable,
- Confirmed non-ischemic, dilated cardiomyopathy
- Active musculo-skeletal conditions
- Ischemic heart disease
- Pulmonary hypertension
- COPD
- Taking vasodilators
- Diabetes mellitus
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Nitrate rich beetroot juice Dietary nitrate Concentrated, beetroot juice is a rich source of dietary nitrate. Nitrate depleted placebo beetroot juice Placebo Placebo beetroot juice is identical to active beetroot juice in every way except nitrate content.
- Primary Outcome Measures
Name Time Method Change between incremental shuttle walk test distance pre and post juice Day 1 and day 8
- Secondary Outcome Measures
Name Time Method Clinic blood pressure Day 1 and day 8 Dyspnoea using self report, validated Borg scale Day 1 and day 8 Plasma nitrate Day 1 and day 8 Oxygen saturation using pulse oximetry Day 1 and day 8 Plasma nitrite Day 1 and day 8