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Clinical Trials/NCT07655596
NCT07655596Not yet recruitingPhase 4

Continuous Infusion Versus Intermittent IV Bolus of Cefazolin: Prevention of Surgical Site Infection During Orthopedic Surgeries in Egyptian Patients.

Helwan University0 sites100 target enrollmentStarted: July 1, 2026Last updated:
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Interventions

Trial Snapshot

Phase
Phase 4
Status
Not yet recruiting
Enrollment
100
Study OverviewStudy DesignEligibility CriteriaArms & InterventionsInvestigatorsRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

A randomized controlled trial on adults who underwent orthopedic surgery. To evaluate the effectiveness of intraoperative continuous infusion (CI) of cefazolin compared with intermittent (INT) cefazolin administration in preventing SSIs in the orthopedic surgical population.

Eligible patients will be randomized in a block design into 2 groups: intervention and control. The intervention group will use continuous infusion of cefazolin (CI), while the control group will follow the traditional presurgical prophylaxis protocol of intermittent cefazolin doses (INT).

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Prevention
Masking
Single (Outcomes Assessor)

Eligibility Criteria

Ages
18 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •Orthopaedic surgical ward patients who underwent major surgery.

Exclusion Criteria

  • •Patients who require reoperation within 30 days.
  • •Immunosuppressant patients.
  • •Patients who are not adherent to the protocol time or dosing, either preoperatively, during, or postoperatively.
  • •Pregnancy or breastfeeding.

Arms & Interventions

Continuous infusion of cefazolin

Experimental

Intervention: Cefazolin 2 g Infusion (Drug)

Intermittent cefazolin injection

Active Comparator

Intervention: Cefazolin 2 GM Injection (Drug)

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Hebatallah Ali Abdeen

Principal Investigator

Helwan University

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