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Clinical Trials/DRKS00000908
DRKS00000908
Completed
Phase 2

Rituximab in Treating Young Patients Who Are Receiving Chemotherapy for B-Cell Non-Hodgkin's Lymphoma or B-Cell Acute Lymphoblastic LeukemiaMulticenter Therapy Study for Children With Mature B-NHL or B-ALL With a Rituximab - Window Before Chemotherapy

niversitäts-KinderklinikPädiatrische Hämatologie und Onkologie0 sites90 target enrollmentMarch 22, 2012

Overview

Phase
Phase 2
Intervention
Not specified
Conditions
C85.1
Sponsor
niversitäts-KinderklinikPädiatrische Hämatologie und Onkologie
Enrollment
90
Status
Completed
Last Updated
last year

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
March 22, 2012
End Date
TBD
Last Updated
last year
Study Type
Interventional
Sex
All

Investigators

Sponsor
niversitäts-KinderklinikPädiatrische Hämatologie und Onkologie

Eligibility Criteria

Inclusion Criteria

  • 1\. Newly diagnosed and histologically/immunohistologically or cytomorphologically/immunologically verified mature B\-NHL or B\-ALL (not: lymphoblastic lymphoma of precursor B\-CELL type, protocol EURO\-LB 02\)
  • 2\. Immunological or immuno\-histo\-chemical proof of a CD20\-expression of the lymphoma cells
  • 3\. Written informed consent and consent for the processing and disclosure of data by each patient and/or their legal guardian.
  • 4\. Diagnosis prior to 19th birthday.
  • 5\. Begin of protocol therapy within the duration of the study
  • 6\. Treatment in one of the participating study clinics
  • 7\. Contraception in women of child\-bearing age
  • 8\. No participation in any other study with the exception of B\-NHL BFM 04
  • 9\. Stratification according to stage, extent of resection, and initial LDH in the therapy arms R2, R3, or R4
  • 10\. Good general health; adequate liver, cardiac, and renal functions.

Exclusion Criteria

  • Pregnant or nursing,
  • Allergies against proteins,
  • Known disease that would preclude protocol therapy with rituximab,
  • Significant therapy prior to protocol therapy

Outcomes

Primary Outcomes

Not specified

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