Influence of Microfiltered-seawater Supplementation and Variable Resistance Training in Blood Pressure, Oxidative Stress, Hepatic, and Renal Biomarkers in Older Women. a 32-week, Double-blinded, Randomized, Placebo-controlled Trial
Not Applicable
Completed
- Conditions
- Blood PressureOxidative StressRenal DiseaseHepatic Impairment
- Interventions
- Dietary Supplement: Resistance training + deep sea waterDietary Supplement: Resistance training + PlaceboDietary Supplement: Control + deep sea waterDietary Supplement: Control + Placebo
- Registration Number
- NCT06600243
- Lead Sponsor
- University of Valencia
- Brief Summary
This study was conducted to investigate the effects of the intake of deep sea water prior to resistance training on blood pressure, oxidative stress and hepatic and renal variables in older women.
- Detailed Description
This study was a 32 weeks, double-blinded, randomized, placebo-controlled trial.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 109
Inclusion Criteria
- (i) women aged ≥65years
- (ii) able to climb 10 stairs without pause and walk 100m without a walker
- (iii) score above 23 points in the mini-mental state examination
- (iv) <1h of physical activity per week throughout the six months before the study
- (v) possess a medical certificate of aptitude to carry out physical activity
Exclusion Criteria
Participants who had suffered:
- (i) any type of musculoskeletal, cardiovascular, hepatic, renal, pulmonary, neurological, or neuromuscular injury or disorder and/or
- (ii) taking any type of drug/supplement that may alter the results of the study (e.g., vitamin C, vitamin E, estrogens, beta-blockers, calcitonin, steroid hormones, etc.)
- (iii) changes in body weight of more than 10% in the year prior to the study
- (iv) have a severe hearing or visual impairment
- (v) participate in another research project (within the last six months) involving an exercise, dietetic and/or pharmaceutical intervention
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Resistance training + deep sea water Resistance training + deep sea water Resistance training with elastic bands prior intake of deep sea water (20ml) twice weekly during 32 weeks. Resistance training + Placebo Resistance training + Placebo Resistance training with elastic bands prior placebo water (20ml) twice weekly during 32 weeks. Control + Deep sea water Control + deep sea water No exercise and intake of deep sea water (20ml) twice weekly during 32 weeks. Control + Placebo Control + Placebo No exercise and intake of placebo water (20ml) twice weekly during 32 weeks.
- Primary Outcome Measures
Name Time Method Malondialdehyde (MDA) pre (week 0) and post (week 32) Oxidative stress biomarker
Oxidized/reduced glutathione ratio (GSH/GSSG) pre (week 0) and post (week 32) Antioxidant enzyme
Interleukin-6 (IL-6) pre (week 0) and post (week 32) Inflammatory biomarker
Vitamin D pre (week 0) and post (week 32) Vitamin
- Secondary Outcome Measures
Name Time Method Glutamic-oxaloacetic transaminase (GOT) pre (week 0) and post (week 32) Hepatic biomarker
Glutamic-pyruvic transaminase (GPT) pre (week 0) and post (week 32) Hepatic biomarker
Gamma- glutamyl transpeptidase (GGT) pre (week 0) and post (week 32) Hepatic biomarker
Alkaline phosphatase enzyme (ALP) pre (week 0) and post (week 32) Hepatic biomarker
Systolic blood pressure (SBP) pre (week 0) and post (week 32) Cardiovascular measure
Diastolic blood pressure (SBP) pre (week 0) and post (week 32) Cardiovascular measure
Up and Go test (UGT) pre (week 0) and post (week 32) Functional test
Age pre (week 0) and post (week 32) Sample demographic description
Height pre (week 0) and post (week 32) Sample demographic description
Weight pre (week 0) and post (week 32) Sample demographic description
Body mass index (BMI) pre (week 0) and post (week 32) Sample demographic description
Fat mass percentage (% fat mass) pre (week 0) and post (week 32) Sample demographic description