Could Microfiltered-seawater Supplementation and Variable Resistance Training Improve Blood Pressure, Oxidative Stress, Hepatic, and Renal Biomarkers in Older Women? a 32-week, Double-blinded, Randomized, Placebo-controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 109
- 主要终点
- Malondialdehyde (MDA)
研究概览
简要总结
This study was conducted to investigate the effects of the intake of deep sea water prior to resistance training on blood pressure, oxidative stress and hepatic and renal variables in older women.
详细描述
This study was a 32 weeks, double-blinded, randomized, placebo-controlled trial.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •(i) women aged ≥65years
- •(ii) able to climb 10 stairs without pause and walk 100m without a walker
- •(iii) score above 23 points in the mini-mental state examination
- •(iv) <1h of physical activity per week throughout the six months before the study
- •(v) possess a medical certificate of aptitude to carry out physical activity
排除标准
- •Participants who had suffered:
- •(i) any type of musculoskeletal, cardiovascular, hepatic, renal, pulmonary, neurological, or neuromuscular injury or disorder and/or
- •(ii) taking any type of drug/supplement that may alter the results of the study (e.g., vitamin C, vitamin E, estrogens, beta-blockers, calcitonin, steroid hormones, etc.)
- •(iii) changes in body weight of more than 10% in the year prior to the study
- •(iv) have a severe hearing or visual impairment
- •(v) participate in another research project (within the last six months) involving an exercise, dietetic and/or pharmaceutical intervention
研究组 & 干预措施
Resistance training + deep sea water
Resistance training with elastic bands prior intake of deep sea water (20ml) twice weekly during 32 weeks.
干预措施: Resistance training + deep sea water (Dietary Supplement)
Resistance training + Placebo
Resistance training with elastic bands prior placebo water (20ml) twice weekly during 32 weeks.
干预措施: Resistance training + Placebo (Dietary Supplement)
Control + Deep sea water
No exercise and intake of deep sea water (20ml) twice weekly during 32 weeks.
干预措施: Control + deep sea water (Dietary Supplement)
Control + Placebo
No exercise and intake of placebo water (20ml) twice weekly during 32 weeks.
干预措施: Control + Placebo (Dietary Supplement)
结局指标
主要结局
Malondialdehyde (MDA)
时间窗: pre (week 0) and post (week 32)
Oxidative stress biomarker
Oxidized/reduced glutathione ratio (GSH/GSSG)
时间窗: pre (week 0) and post (week 32)
Antioxidant enzyme
Interleukin-6 (IL-6)
时间窗: pre (week 0) and post (week 32)
Inflammatory biomarker
Vitamin D
时间窗: pre (week 0) and post (week 32)
Vitamin
次要结局
- Glutamic-oxaloacetic transaminase (GOT)(pre (week 0) and post (week 32))
- Up and Go test (UGT)(pre (week 0) and post (week 32))
- Glutamic-pyruvic transaminase (GPT)(pre (week 0) and post (week 32))
- Gamma- glutamyl transpeptidase (GGT)(pre (week 0) and post (week 32))
- Alkaline phosphatase enzyme (ALP)(pre (week 0) and post (week 32))
- Systolic blood pressure (SBP)(pre (week 0) and post (week 32))
- Diastolic blood pressure (SBP)(pre (week 0) and post (week 32))
- Age(pre (week 0) and post (week 32))
- Height(pre (week 0) and post (week 32))
- Weight(pre (week 0) and post (week 32))
- Body mass index (BMI)(pre (week 0) and post (week 32))
- Fat mass percentage (% fat mass)(pre (week 0) and post (week 32))
研究者
Juan C. Colado
Professor
University of Valencia