Efficacy of unani formulation in the treatment of Lichen Planus

Phase 2

Not yet recruiting

Conditions: Other lichen planus,

Registration Number: CTRI/2023/09/057463

Lead Sponsor: Department of Amraz e Jild wa Zohrawiya

Brief Summary: Lichen planus (LP) is a chronic inflammatory immune mediated disease that more frequently affects the skin and mucosa. Other areas that may be affected include the scalp, hair, nails and mucous membrane of the genitalia.Classic LP is characterized by violaceous, shiny, flat topped polygonal papules of variable sizes.Lichen planus is thought to be a T- cell mediated autoimmune disease, possibly targeting the basal keratinocyte. Exact Etiopathogenesis of LP is still unclear.The diagnosis of Lichen planus is clinical; however, it may be supplemented by histopathology.Aim of management of LP and its variants to control symptoms and to decrease time from onset to resolution. Treatment of cutaneous Lichen planus in conventional system of medicine is oral and topical corticosteroids, antihistamines, Vitamin A, Antibiotics and phototherapy /PUVA etc.

There are some conditions mentioned in Unani system of medicine which has resemblance with lichen planus. It seems to be a type of Amraze Basoorat which is mentioned in almost all classical books.According to itâ€™s clinical presentation itâ€™s features mimics with the clinical presentation of basoor asfar and basoor aswad . The need of this study is to evaluate effectiveness of this classical unani preparation clinically, in this disease.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 30

Inclusion Criteria

Clinically diagnosed cases of Lichen Planus Clinically stable patients Patients of either sex Patients having age group of 18 to 60 years Patients who are willing to be a part of our study.

Exclusion Criteria

Patient below and above the age of 18 years and 60 years Patients who are not willing to be a part of study Patient suffering from any other type of skin diseases like psoriasis Eczema Seborrheic Dermatitis dermatophytosis and Lupus Erythematosus Patient suffering from systemic and metabolic diseases like DM and prediabetes severe asthma Cardiac diseases Chronic Renal failure History of taking Conventional and Alternative Medicine therapy of present disease within the previous 7 days Pregnant & Lactating Women.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Improvement in Photograph of affected area.	Assessment of all parameters at inititation of the study at 0 day 15 day 30 day & 45 day of the study.
Improvement in Lichen Planus Severity Index	Assessment of all parameters at inititation of the study at 0 day 15 day 30 day & 45 day of the study.
Improvement in Dermatology Life Quality Index.	Assessment of all parameters at inititation of the study at 0 day 15 day 30 day & 45 day of the study.

Secondary Outcome Measures

Name	Time	Method
Itching	Scaling

Trial Locations

Locations (1): Ajmal Khan Tibbya College and hospital
🇮🇳
Aligarh, UTTAR PRADESH, India
Ajmal Khan Tibbya College and hospital
🇮🇳Aligarh, UTTAR PRADESH, India
Dr Malik Nuzhat Fatima
Principal investigator
8439778035
maliknuzhat2015@gmail.com