Oral Chemotherapy along with radiation therapy for cervical cancer
- Conditions
- Health Condition 1: C539- Malignant neoplasm of cervix uteri, unspecified
- Registration Number
- CTRI/2022/11/047794
- Lead Sponsor
- Cancer Institute WIA
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1. Untreated squamous cell carcinoma of cervix who are planned for definitive
chemoradiation
2. Cisplatin ineligible â?? Sensorineural hearing loss, Sensory/Motor neuropathy
> grade 2, Borderline renal dysfunction (Calculated creatinine clearance > 30
- 60ml/min), or patientâ??s unwillingness to receive cisplatin/intravenous
chemotherapy.
3. Eastern Cooperative Oncology Group performance status of 0, 1, or 2.
4. Adequate Aspartate transaminase (AST) and Alanine transaminase (ALT)
within 3 times the upper limit of normal (ULN), serum bilirubin less than 2
mg/d
1. Preexisting coronary heart disease (Unstable angina, Echocardiography
showing regional wall motion abnormalities or ejection fraction < 50 %),
NYHA (Newyork Heart Association) class > 2
2. Known dihydropyramidine dehydrogenase (DPD) mutation
3. Creatinine clearance < 30ml/min
4. Uncontrolled comorbid illness
5. Inflammatory bowel disease
6. Patient taking oral anti coagulants like warfarin
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method