The Effect of Dosage of Caffeine on Intraocular Pressure in Healthy Subjects
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Chiang Mai University
- Enrollment
- 60
- Locations
- 2
- Primary Endpoint
- change from baseline in intraocular pressure (mmHg)after caffeine intake
Study Overview
Brief Summary
The goal of the study is to determine the effect of different doses of caffeine on intraocular pressure. We hypothesized that higher dosage of caffeine would increase intraocular pressure more than lower doses.
Eligible subjects will be randomized into three groups:
- group 1: intake of decaffeinated coffee
- group 2: intake of coffee with lower caffeine dose
- group 3: intake of coffee with higher caffeine dose
Intraocular pressure will be measured at 0, 30, 60 and 90 minutes after coffee intake.
Detailed Description
decaffeinated coffee contains 0.5-2 mg of caffeine regular dose coffee contains 91.8 mg of caffeine high dose coffee contains 144 mg of caffeine
all three groups' intraocular pressure will be measured with the Goldmann applanation tonometer at 4 timepoints:
- 0 minutes (baseline)
- 30 minutes after intake
- 60 minutes after intake
- 90 minutes after intake
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Diagnostic
- Masking
- Triple (Participant, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 20 Years to 35 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •healthy subjects
- •normal central corneal thickness
- •normal baseline intraocular pressure
Exclusion Criteria
- •any ocular disease
- •baseline intraocular pressure over 21 mmHg
- •central corneal thickness less than 520 microns or more than 540 microns
Outcomes
Primary Outcomes
change from baseline in intraocular pressure (mmHg)after caffeine intake
Time Frame: 0, 30 minutes, 60 minutes, 90 minutes post-caffeine intake
intraocular pressure measured at 4 timepoints: 1. 0 minutes (baseline) 2. 30 minutes after intake 3. 60 minutes after intake 4. 90 minutes after intake
Secondary Outcomes
No secondary outcomes reported
Investigators
Damrong Wiwatwongwana
M.D.
Chiang Mai University