Sevoflurane Versus Propofol in Endovascular Coiling of Cerebral Aneurysm

Completed

• Conditions: Propofol; Sevoflurane
• Interventions: Drug: Anesthesia Agent

• Registration Number: NCT06666959
• Lead Sponsor: Tongji Hospital

Brief Summary

The goal of this observational study is to learn about the anti-inflammatory effects of anesthetics on patients undergoing endovascular coiling of cerebral aneurysm. The main question it aims to answer is:

Does sevoflurane or propofol affect the inflammatory response in subarachnoid hemorrhage?

Participants already undergoing endovascular coiling of cerebral aneurysm will have their serum levels of inflammatory factors measured.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-05-01
• Primary Completion: 2024-02-08
• Study Completion: 2024-05-08
• Status Verified: 2024-10
• Study First Submitted: 2024-10-26
• Study First Submitted QC: 2024-10-28
• Last Update Submitted: 2024-10-28
• Study First Posted: 2024-10-31
• Last Update Posted: 2024-10-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Consecutive patients aged 18 years and older presenting to the Tongji hospital for endovascular coiling of cerebral aneurysm were eligible for enrollment.

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Exclusion Criteria

• have an endocrine system disease
• pregnancy
• have other brain disorders
• take drugs that alter endocrine hormones
• receive perioperative blood derivatives

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
patients undergoing endovascular coiling of cerebral aneurysm in Tongji hospital	Anesthesia Agent	The present clinical study was carried out with the aim of determine whether the inflammatory effect differs when using propofol or sevoflurane anesthesia.

Primary Outcome Measures

Name	Time	Method
Concentration of interleukin-10	From enrollment to 3 months postoperation	Test the concentration of interleukin-10 of the participants

Secondary Outcome Measures

Name	Time	Method
Concentration of interleukin-1	From enrollment to 3 months postoperation	Test the Concentration of interleukin-1 in participants
Concentration of interleukin-2	From enrollment to 3 months postoperation	Test the concentration of interleukin-2 in participants
Concentration of interleukin-6	From enrollment to 3 months postoperation	Test the concentration of interleukin-6 in participants
Concentration of interleukin-8	From enrollment to 3 months postoperation	Test the concentration of interleukin-8 in participants
Concentration of tumor necrosis factor	From enrollment to 3 months postoperation	Test the concentration of tumor necrosis factor in participants
Concentration of S100B	From enrollment to 3 months postoperation	Test the concentration of S100B in participants
length of stay	through study completion, an average of 6 months	The time from admission to discharge
costs	through study completion, an average of 6 months	Hospitalization expenses
Glasgow Coma Score	From enrollment to 3 months postoperation	The scores are ranging from 3 to 15. And higher scores mean a betterr outcome .

Trial Locations

Locations (1)

Department of Neurosurgery; 🇨🇳 Wuhan, Hubei, China