NAVA vs Pressure Support After Cardiac Surgery, a Physiological Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 12
- 试验地点
- 2
- 主要终点
- End expiratory lung impedance
研究概览
简要总结
The study compares two different ventilation modes, Pressure support ventilation vs. Neuronally Adjusted Ventilatory Assist, in postcardiac surgery patients. Of special interest is shunt and alveolar deadspace and ventral vs. dorsal ventilation.
详细描述
The aim of the study is to compare two different ventilation modes in complicated postcardiac surgery patients, who need ventilatory support during weaning phase, in the Cardiothoracic Intensive Care Unit. The two different ventilation modes are Neuronally Adjusted Ventilatory Assist (NAVA) and Pressure Support ventilation. NAVA ventilation mode have been introduced a couple of years ago as an alternative to pressure support. The advantage of NAVA mode compared to pressure support is a better synchrony between patient and ventilator in the inspired and expired phases. Maybe there are also physiological advantages of the NAVA mode, which we want to study in the present study.
All patients have three measurement periods. 1) Pressure support during 20 min, NAVA equilibration period of 30 min, followed by 2) NAVA ventilation for 20 min, pressure support equilibration period of 30 min and 3) pressure support for 20 min. Blood gases and cardiac output measurements is performed before and after each measurement period. Regional ventilation is measured by Electric Impedance Tomography (EIT).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
盲法说明
The investigator works as physician at the Department of Intensive Care. The participants are patients.
入排标准
- 年龄范围
- 18 Years 至 84 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Complicated Post Cardiac surgery patients in the ventilator weaning phase.
- •Patients requiring assisted ventilation
- •Respiratory and circulatory stable patients
- •Sedated patients, RASS -2 to -3
排除标准
- •Transplanted patients
- •Pleural effusion.
研究组 & 干预措施
NAVA vs Pressure Support
Control (pressure support) - NAVA - Control (Pressure Support) Intervention is NAVA
干预措施: NAVA (Device)
结局指标
主要结局
End expiratory lung impedance
时间窗: Through study completion, within approximately 18 months
Measured by Electric Impedance Tomography
Alveolar shunt
时间窗: Through study completion, within approximately 18 months
Calculated from mixed venous and arterial blood gases
Ventilation distribution
时间窗: Through study completion, within approximately 18 months
Redistribution of ventilation , dorsally vs. ventrally
Alveolar dead space
时间窗: Through study completion, within approximately 18 months
Calculated from blood gases and end tidal pCO2,using standard formulae
PaO2/FiO2
时间窗: Through study completion, within approximately 18 months
Arterial oxygenation
次要结局
未报告次要终点
研究者
Andreas Martinsson
MD
Göteborg University