Investigation of the relationship between immune system and coagulation system in patient with cardiac arrest outside the hospital
- Conditions
- Out-of-hospital cardiac arrest
- Registration Number
- JPRN-UMIN000039242
- Lead Sponsor
- Hokkaido University Hospital
- Brief Summary
Patients with MODS exhibited higher histone levels than those without MODS during the early phase of the post-resuscitation period.Severe endothelial injury and higher thrombin and plasmin generation were observed in the MODS group. Plasma levels of histones were positively correlated with those of soluble fibrin immediately after resuscitation and PIC 3 h after arriving at the hospital. This correlation was prominent in the patient population with MODS.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 62
Not provided
Patients with cardiac arrest due to trauma, acute aortic dissection or ruptured aortic aneurysm Patients who take anticoagulants Patients with coagulofibrinolytic disorders as underlying diseases Other patients who are judged inappropriate by the principal investigator
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Severity of organ dysfunction, assessed by Sequential Organ Failure Assessment (SOFA) score
- Secondary Outcome Measures
Name Time Method The levels of histone H3, interleukin-6, and various markers of coagulation and fibrinolysis Outcome (organ dysfunction, 28-days mortality and hospital death) Impact of DIC on outcome