Investigation of the relationship between innate immune responses and coagulofibrinolytic responses in patients with out-of-hospital cardiac arrest - Investigation of the relationship between innate immune responses and coagulofibrinolytic responses in patients with out-of-hospital cardiac arrest

Patients with MODS exhibited higher histone levels than those without MODS during the early phase of the post-resuscitation period.Severe endothelial injury and higher thrombin and plasmin generation were observed in the MODS group. Plasma levels of histones were positively correlated with those of soluble fibrin immediately after resuscitation and PIC 3 h after arriving at the hospital. This correlation was prominent in the patient population with MODS.