Optimal Measurement of Spleen Stiffness Among Veterans With Metabolic Dysfunction-Associated Steatotic Liver Disease
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Spleen Stiffness measurement
研究概览
简要总结
A growing number of people are being diagnosed with fatty liver disease, also known as metabolic-dysfunction associated liver disease (MASLD). Fatty liver disease can unknowingly progress to serious liver disease and even permanent scarring (cirrhosis).The purpose of this research is to learn the best way to detect serious liver disease as early as possible in patients with fatty liver disease by measuring the stiffness of the spleen. Secondarily, the study hopes to understand how the stiffness of the spleen relates to the severity of liver disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Able to consent for participation in a clinical study
- •Able to read and comprehend English
- •Evidence of fatty liver disease on previous liver biopsy, imaging or clinical documentation
排除标准
- •Known decompensated cirrhosis or hepatocellular carcinoma
- •Absence of spleen
- •Documentation of alcohol use disorder or alcohol use greater than 20g/day for women or greater than 30 g/day for men
- •Unable to provide informed consent
研究组 & 干预措施
Spleen Stiffness Measurements
Participants with metabolic-dysfunction associated steatotic liver disease will undergo liver and spleen stiffness measurements using vibration-controlled transient elastography
干预措施: Vibration-controlled transient elastography (Device)
结局指标
主要结局
Spleen Stiffness measurement
时间窗: 1 year
Percent of participants with valid spleen stiffness measurements using vibration controlled transient elastography
次要结局
未报告次要终点
研究者
Nicholas Hoppmann
Physician
William Jennings Bryan Dorn VA Medical Center