Effects of dialysate potassium concentration on intradialytic hypertension: a multicenter, double blind, randomized crossover study

Phase 2

Completed

• Conditions: Intradialytic hypertension; Dialysate potassium concentration

• Registration Number: TCTR20200604005
• Lead Sponsor: ampang hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-06-04
• Study Completion: 2022-01-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

1. ESRD patients (defined by Kidney Disease Initiative Global Outcome (KDIGO)
Guideline 2012) requiring chronic hemodialysis
2. Hemodialysis vintage more than 12 weeks
3. Hemodialysis with at least 2 sessions per week
4. History of intradialytic hypertension (defined by an increase in systolic blood pressure >15 mmHg or mean arterial pressure >10 mmHg during hemodialysis) at least 30% of their dialysis sessions during the past 12 weeks

Exclusion Criteria

1. Serum potassium >5.5 mEq/L or <2.5 mEq/L
2. Active cardiac, pulmonary or hepatobiliary tract disease
3. Active infection or sepsis
4. Active malignancy
5. Cirrhosis
6. Prior prescribed with dialysate potassium concentration 3 mmol/L in past 2 weeks
7. Interdialytic weight gain more than 6%

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Intradialytic hemodynamic parameters During hemodialysis Blood pressure (mmHg), heart rate (bpm)

Secondary Outcome Measures

Name	Time	Method
umber of events of intradilytic hypertension During hemodialysis Number of events (%) ,Serum potassium End of study mEq/