Biochemical markers of coronary artery disease in Type 2 diabetes mellitus:a cross sectional study from Dehradun Uttrakhand
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 524
- 试验地点
- 2
- 主要终点
- Identication of specific biochemical markers associated with the presence or risk of Coronary artery disease in type 2 diabetes patients.
研究概览
简要总结
This study aims to explore the biochemical markers associated with coronary artery disease(CAD) in individuals with type 2 diabetes in Dehradun. CAD is a common complication among type 2 diabetic patients due to the detrimental effect of chronic hyperglycemia and associated risk factors such as dyslipidemia, inflammation and oxidative stress. The study will be a Cross-sectional investigation, where biochemical markers will be measured in a sample of all four study groups.by examining these markers, the research will provide valuable insights into the specific biochemical alteration that predispose diabetic individual to CAD, with a particular focus on the unique metabolic profile of the population in Dehradoon.the output of this study could help in identifying early diagnostic biomarkers, improving risk prediction, and developing targeted therapeutic strategies for CAD in type 2 patients.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 40.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Type 2 Diabetes Diagnosis: participant must be diagnosed with type 2 diabetes(confirmed by clinical criteria or medical records.
- •2.Age range: studies may focus on specific age groups,such as adult aged 40-70 years,as CAD risk increases with age.
- •3.Presence of CAD or carddiovascular risk: Participants should either have CAD (diagnosed through imaging or clinical signs)or be at high risk of devloping CAD,based on risk factor like high blood pressure,obesity,or smoking.
- •4.Measurement of Biochemical Markers: .studies that measures specific biochemical markers associated with CAD markers(homocysteine,lipoprotein a,apolipoproteins 5.Study design: cross sectional,observational study.
排除标准
- •1.Other type of Diabetes: .Individual with type 1 diabetes, gestational diabetes, or other non-type 2 diabetes condition are excluded to focus on type 2 diabetes specifically.
- •2-Non cardiovascular disease: participants with condition such as chronic kidney disease, liver dysfunction, cancer, or other major comorbidities that might confound the relationship between CAD and biochemical markers in type 2 diabetes.
- •3-Acute or uncontrolled illness: Exclusion of individuals with acute infections, acute myocardial infarction, or other condition that might temporarily elevate biochemical markers unrelated to chronic CAD.
- •4-Pregnancy: Pregnant women are typically excluded due to the physiological and hormonal changes during pregnancy that can affect biochemical markers and CAD risk.
- •5-Medication: Individuals on certain medications(e.g,corticosteroids,high-dose statins, or immunosuppressive drugs)that might influence CAD markers in ways unrelated to the diabetes condition may be excluded.
结局指标
主要结局
Identication of specific biochemical markers associated with the presence or risk of Coronary artery disease in type 2 diabetes patients.
时间窗: 6 weeks
Lipid profile and glycemic control
时间窗: 6 weeks
次要结局
- Prevalance of Coronary artery disease in study population.(Association between clinical parameters & biochemical markers.)
研究者
Richa Negi
SBSU Balawala Dehradun