Identification of Anaphylactogenic Antibodies in Peanut Allergy
- Conditions
- Peanut Allergy
- Registration Number
- NCT02821286
- Lead Sponsor
- University of Zurich
- Brief Summary
This project intends the analysis and profiling of specific antibodies against major peanut allergens in peanut allergic individuals and molecular cloning of human antibodies against major peanut allergens.
- Detailed Description
* Characterization of patient samples reactivity (sera obtained from blood) against major peanut allergens.
* Isolation of antibody-producing B cells.
* Molecular cloning of peanut-specific antibodies from antibody gene sequences obtained from B cells.
* Biophysical and functional characterization of isolated antibodies
Recruitment & Eligibility
- Status
- ENROLLING_BY_INVITATION
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
- Participants have a described clinical history of peanut allergy and/or are sensitized to peanut allergens (as evidenced by positive skin prick test and allergen-specific IgE testing)
- Male and female subjects older than 3 years
- Written informed consent
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Exclusion Criteria
- age below three years
- patients suffering from any disease where blood withdrawals might impact the patients' health status such as known anemia.
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Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Analysis and profiling of specific antibodies against major peanut allergens in samples derived from peanut allergic patients. June 2016 to May 2018
- Secondary Outcome Measures
Name Time Method