Indomethacin and fertility outcomes in infertile women with poor ovarian response

Phase 3

Recruiting

• Conditions: Female infertility due to poor ovarian response.; Female infertility of other origin; N97.8

• Registration Number: IRCT20160524028038N12
• Lead Sponsor: Bandare-abbas University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 7 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

Patients aged 18 to 45 years
Absence of contraindications to the use of indomethacin
Normal semen analysis
poor ovarian response

Exclusion Criteria

Patients with other endocrine disorders such as hyperprolactinemia, PCOS, etc.
History of ovarian surgery or ovarian endometrioma
Smoker
Cardiovascular disorders
Receiving drugs affecting the metabolism of indomethacin
Unwillingness to cooperate
History of peptic ulcer or recurrent active gastric ulcer
History of gastrointestinal lesions
Allergy to indomethacin or any of the ingredients of this product
History of acute attacks of asthma, urticaria, or rhinitis as a result of treatment with aspirin or other non-steroidal anti-inflammatory drugs.
Drug abuse
History of proctitis or recent rectal bleeding
Having nasal polyps with angioneurotic edema

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Oocyte Quality. Timepoint: 2-3 hrs. after oocyte collection. Method of measurement: Microscopic Evaluation.;Number of retried oocyte. Timepoint: On day of oocyte retrieval. Method of measurement: Counting number of total oocytes with microscope.;Number of embryo. Timepoint: On the 2nd day after ICSI. Method of measurement: Observation with microscope.