Use of AMP to Improve Tissue Delivery of Adenosine
Trial Snapshot
- Phase
- Phase 1
- Status
- Terminated
- Enrollment
- 13
- Locations
- 1
- Primary Endpoint
- Interstitial Adenosine Levels
Study Overview
Brief Summary
Adenosine and AMP are substances normally present in the body. Adenosine is also given for the treatment of some heart rhythm problems and may be used to reduce heart damage during heart attacks. The problem in using adenosine is that it is taken up by cells and, therefore, very little of the adenosine we give by vein or in the artery actually reaches the tissue. We propose to use AMP as a way to improve delivery of adenosine. AMP is inactive by itself, but is converted to adenosine in tissue. We hope that by giving AMP we will increase levels of adenosine in tissue. To see if this is true, we will give either adenosine or AMP into the forearm artery while we measure how much adenosine reaches the forearm tissue.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Healthy volunteers
- •Age 18-65
- •Non smokers
Exclusion Criteria
- •Any chronic disease
Arms & Interventions
Adenosine then Adenosine Mono Phosphate (AMP)
Intrarterial infusion of adenosine then same subject switch to AMP one month apart.
Intervention: Adenosine (Drug)
Adenosine then Adenosine Mono Phosphate (AMP)
Intrarterial infusion of adenosine then same subject switch to AMP one month apart.
Intervention: Adenosine Mono Phosphate (AMP) (Drug)
Adenosine Mono Phosphate (AMP) then adenosine
Intrarterial infusion of AMP then same subject switch to Adenosine one month apart.
Intervention: Adenosine (Drug)
Adenosine Mono Phosphate (AMP) then adenosine
Intrarterial infusion of AMP then same subject switch to Adenosine one month apart.
Intervention: Adenosine Mono Phosphate (AMP) (Drug)
Outcomes
Primary Outcomes
Interstitial Adenosine Levels
Time Frame: Microdyalysis samples for adenosine, were collected for 15 minutes at each stage of the study (baseline and each dose of adenosine or AMP)
Secondary Outcomes
No secondary outcomes reported
Investigators
Italo Biaggioni
Professor of Medicine
Vanderbilt University Medical Center