Impact of Local Anesthesia Type on Cancer Detection Rate in Transrectal Ultrasound Guided Prostate Biopsy
Overview
- Phase
- Phase 4
- Intervention
- intrarectal lidocaine gel
- Conditions
- Adenocarcinoma of Prostate
- Sponsor
- Bagcilar Training and Research Hospital
- Enrollment
- 422
- Locations
- 1
- Primary Endpoint
- cancer detection rate with anesthesia type
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
Transrectal ultrasound guided prostate biopsy (TRUS-Bx) is the gold standard method for prostat cancer diagnosis. Cancer detection rate is an important issue in TRUS-Bx. Effective biopsy protocol is necessary to enhance cancer detection rate during the procedure. Patient tolerance may improve the protocol effectiveness and quality.
Adequate patient tolerance with optimal local anesthesia may enhance cancer detection rate in TRUS-Bx.
Detailed Description
In transrectal ultrasound guided prostate biopsy ultrasound's probe manipulation is necessary for effective biopsy. Patient discomfort and pain frequently occurs with manipulation of probe during transrectal ultrasound guided prostate biopsy and this situation may qualify of the achievement of this procedure. In this study, we aimed to describe the impact of different two local anesthesia types on cancer detection rate in transrectal ultrasound guided prostate biopsy.
Investigators
Mustafa Zafer Temiz
principal investigator
Bagcilar Training and Research Hospital
Eligibility Criteria
Inclusion Criteria
- •Patients who underwent transrectal ultrasound guided prostate biopsy because of elevated serum PSA levels and/or suspicious rectal examination of prostate.
Exclusion Criteria
- •Previous TRUS-Bx and prostatic operations(TUR-P, open prostatectomy, etc..) history, treatment for prostate carcinoma, usage of finasteride and dutasteride.
Arms & Interventions
intrarectal lidocaine gel
transrectal ultrasound guided prostate biopsy was performed with intrarectal lidocaine gel anesthesia: 10 minutes before the procedure % 2 lidocaine hydrochloride gel instilated into the rectum for local anesthesia
Intervention: intrarectal lidocaine gel
periprostatic nerve blockade
transrectal ultrasound guided prostate biopsy was performed with intrarectal lidocaine gel anesthesia: 10 minutes before the procedure transrectal ultrasound guided 10 ml prilocaine and serum physiologic blend (5ml %2 prilocaine and 5 ml serum physiologic) injected separetly 5ml right and 5ml left junction between the prostate base and seminal vesicle.
Intervention: periprostatic nerve blockade
Outcomes
Primary Outcomes
cancer detection rate with anesthesia type
Time Frame: finally pathologic evaluation within 2-3 weeks