Effects of Aerobic Exercise on Obsessive-Compulsive Disorder Symptoms and Cognitive Flexibility
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Cognitive flexibility will be assessed using a probabilistic reversal learning (PRL) task called the Lucky Picture Selection Game.
研究概览
简要总结
The purpose of this study is to examine the acute effects of exercise on cognitive flexibility and symptom reactivity. The main questions it aims to answer are:
Does moderate intensity physical activity reduce subjective distress, compulsive urges, and intrusions- and increase cognitive flexibility- in adults with obsessive-compulsive disorder compared to low-intensity physical activity?
Researchers will compare low- to moderate-intensity exercise to see if moderate physical activity increases cognitive flexibility and reduces symptom reactivity in adults with obsessive-compulsive disorder (OCD).
Participants will:
Complete self-report surveys, psychiatric interviews, and cognitive tasks.
Be assigned to either a low- or moderate-intensity exercise condition and complete physical activity.
Repeat cognitive and symptom measures following the exercise intervention.
详细描述
The proposed study aims to determine if moderate physical activity increases cognitive flexibility (aim 1) and reduces symptom reactivity (aim 2) in adults with obsessive-compulsive disorder (OCD).
Adults with obsessive-compulsive disorder (OCD) will be asked to participate in this study, which consists of two visits in addition to a self-report survey between these two visits.
This study will randomize 50 adults with obsessive-compulsive disorder (OCD) for aims 1 and 2.
First, participants will complete a phone screen to determine preliminary eligibility. During Session 1, participants will be consented and complete the diagnostic interview for anxiety, mood, and obsessive-compulsive related disorders (DIAMOND), the baseline probabilistic reversal learning (PRL) task, the symptom reactivity task, and self-report measures in-person. Between sessions 1 and 2, participants will be asked to complete several self-report measures via RedCap survey link.
Session 2 will take place 7-10 days following Session 1. Upon arrival to the lab, participants will be randomized (1:1) to a moderate-intensity physical activity or a low-intensity control condition. Randomization will be stratified based on sex and age to minimize demographic differences. Participants will be blind to allocation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 64 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults, age 18 to 64 years
- •Meet diagnostic criteria for OCD (per the DIAMOND)
- •Stable psychiatric or medication treatment (if ≥4-weeks), or if no active treatment. Psychotropic medications will be reviewed with the study psychiatrist on a case by case basis.
排除标准
- •Active or unmanaged psychotic disorders, pervasive developmental disorders, bipolar disorder, current substance use disorder (moderate-to-severe), or high risk for suicide (defined as attempt, plan, or intent within past 3 months)
- •Documented motor impairments and medical condition(s) that prohibit physical exercise
- •Those who are pregnant or trying to become pregnant
研究组 & 干预措施
Moderate-Intensity Exercise
干预措施: Moderate-Intensity Exercise (Behavioral)
Low-Intensity Exercise
Control
干预措施: Low-Intensity Exercise (Behavioral)
结局指标
主要结局
Cognitive flexibility will be assessed using a probabilistic reversal learning (PRL) task called the Lucky Picture Selection Game.
时间窗: Cognitive flexibility will be initially measured on day 1. Follow-up administrations will be completed 7-10 days later after the exercise intervention during session 2.
Symptom reactivity will be assessed using the Braga Obsessive Compulsive Symptom Image Set (BOCI).
时间窗: Symptom reactivity will be initially measured on day 1. Follow-up administrations will be completed 7-10 days later after the exercise intervention during session 2.
Exercise intensity will be measured using a PolarTech chest-strap HR monitor.
时间窗: Exercise intensity will be measured during 7-10 days after baseline, during session 2.
Exercise intensity will be measured as a function of maximum heart rate (70% Max HR for moderate intensity condition and 40-50% max heart rate for low intensity condition).
次要结局
未报告次要终点
研究者
Thomas Adams, PhD
Associate Professor
Yale University