Emergency Curative Resection of Colorectal Cancer

Completed

• Conditions: Oncologic Complications and Emergencies; Colorectal Cancer
• Interventions: Procedure: Curative resection of colorectal cancer

• Registration Number: NCT04288284
• Lead Sponsor: University of Alexandria

Brief Summary

The feasibility and efficacy of emergency curative resection of complicated colorectal cancer is still controversial. This prospective study aim is to assess surgical and oncologic outcomes after emergency compared to elective curative resection of colorectal cancer

Detailed Description

60 consecutive patients presented with complicated colorectal cancer managed by emergency surgery were included and compared to another 155 consecutive patients admitted during the same period with uncomplicated colorectal cancer managed by elective surgery. Both groups were compared regarding curative resection rate, early postoperative mortality and morbidity, 3-years tumor recurrence and survival rates.

Study Timeline

• Study Start: 2015-01
• Primary Completion: 2019-12
• Status Verified: 2020-02
• Study Completion: 2020-02
• Study First Submitted: 2020-02-25
• Study First Submitted QC: 2020-02-25
• Last Update Submitted: 2020-02-25
• Study First Posted: 2020-02-28
• Last Update Posted: 2020-02-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 215

Inclusion Criteria

• All patients presented with Potentially operable colorectal cancer
• No clinical or radiological evidence of metastatic disease

Exclusion Criteria

• Patients received preoperative chemoradiation
• Patients with clinical or radiological evidence of metastatic disease
• Patients with intraoperative evidence of metastatic disease
• Patients with intraoperative evidence of irresectable disease
• Patients with incomplete follow up

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Emergency group	Curative resection of colorectal cancer	Patients presented to emergency by complicated colorectal cancer ( Obstruction, bleeding or perforation)
Elective group	Curative resection of colorectal cancer	Patients presented with uncomplicated colorectal cancer for resection treatment

Primary Outcome Measures

Name	Time	Method
Adequate oncologic resection	histopathological assessment of surgical specimens within 2 weeks postoperative	Negative resection margins + adequate lymphadenectomy ( Lymph Nodes retrieved \> 12)
early postoperative morbidity after curative resection of colorectal cancer	within 90 days after surgery	surgery-related complications
early postoperative mortality after curative resection of colorectal cancer	within 90 days after surgery	early death due to cause related to surgery

Secondary Outcome Measures

Name	Time	Method
Tumor recurrence	By the end of the 3 years follow up period	either local or distant
Disease free survival	By the end of the 3 years follow up period	% of patients survived without recurrence
Overall survival	By the end of the 3 years follow up period	% of all patients survived either with or without recurrence