Arterial Stiffness in Chronic Kidney Disease

Completed

• Conditions: Chronic Kidney Disease

• Registration Number: NCT01770847
• Lead Sponsor: University of Edinburgh

Brief Summary

Diurnal variations in the cardiovascular system apparent in healthy individuals, are different in chronic kidney disease patients. Therefore, diurnal variations in arterial stiffness may also differ in chronic kidney disease patients. This study aims to identify and evaluate diurnal variations in arterial stiffness in chronic kidney disease patients and compare them to those in age matched healthy controls.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-11
• Study First Submitted: 2012-11-28
• Study First Submitted QC: 2013-01-15
• Study First Posted: 2013-01-18
• Primary Completion: 2013-12
• Status Verified: 2017-11
• Last Update Submitted: 2017-11-14
• Last Update Posted: 2017-11-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Systolic blood pressure <160 whether or not on antihypertensive medication
• diastolic blood pressure <100mmHg whether or not on antihypertensive medication
• Chronic kidney disease stage 2-5

Exclusion Criteria

• Systolic blood pressure ≥160mmHg
• Diastolic blood pressure ≥100mmhg
• Significant comorbidity (investigator opinion but to include alcoholism and terminal illness)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Diurnal variations in arterial stiffness	Over one 26 hour period arterial stiffness measurements will be obtained every 30 minutes from 7am to 12am and every 60 minutes from 12am to 7am	The principal objective of this study is to evaluate whether diurnal variations in arterial stiffness are blunted in chronic kidney disease compared to healthy age matched controls

Secondary Outcome Measures

Name	Time	Method
Diurnal variations in aortic and brachial blood pressure	Over one 26 hour period blood pressure measurements will be obtained every 30 minutes from 7am to 12am and every 60 minutes from 12am to 7am	Secondary objective of this study is to evaluate whether diurnal variations in aortic and brachial blood pressure are blunted in chronic kidney disease compared to healthy age matched controls
Relationship between changes in blood pressure and arterial stiffness	Over one 26 hour period	Secondary objective of this study is to evaluate whether diurnal variations in arterial stiffness are dependent on changes in blood pressure in both chronic kidney disease patients and age matched controls.

Trial Locations

Locations (1)

Clinical Research Centre, 2nd Floor Western General Hospital; 🇬🇧 Edinburgh, United Kingdom