Diurnal Variations in Arterial Stiffness in Patients With Chronic Kidney Disease and Healthy Age Matched Controls
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Diurnal variations in arterial stiffness
研究概览
简要总结
Diurnal variations in the cardiovascular system apparent in healthy individuals, are different in chronic kidney disease patients. Therefore, diurnal variations in arterial stiffness may also differ in chronic kidney disease patients. This study aims to identify and evaluate diurnal variations in arterial stiffness in chronic kidney disease patients and compare them to those in age matched healthy controls.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 79 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Systolic blood pressure <160 whether or not on antihypertensive medication
- •diastolic blood pressure <100mmHg whether or not on antihypertensive medication
- •Chronic kidney disease stage 2-5
排除标准
- •Systolic blood pressure ≥160mmHg
- •Diastolic blood pressure ≥100mmhg
- •Significant comorbidity (investigator opinion but to include alcoholism and terminal illness)
结局指标
主要结局
Diurnal variations in arterial stiffness
时间窗: Over one 26 hour period arterial stiffness measurements will be obtained every 30 minutes from 7am to 12am and every 60 minutes from 12am to 7am
The principal objective of this study is to evaluate whether diurnal variations in arterial stiffness are blunted in chronic kidney disease compared to healthy age matched controls
次要结局
- Diurnal variations in aortic and brachial blood pressure(Over one 26 hour period blood pressure measurements will be obtained every 30 minutes from 7am to 12am and every 60 minutes from 12am to 7am)
- Relationship between changes in blood pressure and arterial stiffness(Over one 26 hour period)