Comparative effect of Lorazepam with Midazolam in sedative of patients under mechanical ventilatin hospitalized

Phase 3

Recruiting

Conditions: Patients under mechanical ventilation admitted to the intensive care unit.

Registration Number: IRCT20220424054631N1

Lead Sponsor: Oroumia University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 110

Inclusion Criteria

Pulmonary patients under mechanical ventilation with appropriate level of consciousness (equivalent to GCS=10)
Age 18-65 years
Patients who have not received benzodiazepines in the last 72 hours

Exclusion Criteria

Patients with inadequate level of consciousness GCS <10
Patients with unstable hemodynamics
Allergy to benzodiazepines or contraindications to the use of benzodiazepines
Age under 18 or over 65 years
Patients with neurological disorders, kidney or liver failure
Patients who have recently received or are dependent on long-acting benzodiazepines

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparison of the sedative effect of lorazepam with midazolam. Timepoint: Patients will be assessed at injection start times of 15 minutes, 30 minutes, 1 hour, 3 hours, 6 hours, and 12 hours after the start of the infusion. Method of measurement: During current study patients' demographic information (age and sex), body mass index, blood pressure, heart rate, respiratory rate, oxygen saturation( via pulse oximetry), level of consciousness (by Glasgow coma scale) and level of sedation ( by Richmond sedation scale and Ramsay sedation scale) will be recorded in a checklist prepared by the researcher. Also, the total amount of midazolam and lorazepam that will be used, their prices, duration of mechanical ventilation, duration of hospitalization ( either in intensive care unit or ward) and the mortality rate of patients will be recorded.

Secondary Outcome Measures