The measurement of energy needs in adult patients receiving Extracorporeal Membrane Oxygenation (ECMO) support

Not Applicable

Completed

• Conditions: Critical illness; Extracorporeal Membrane Oxygenation; Emergency medicine - Other emergency care; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12619000760178
• Lead Sponsor: The Alfred, Alfred Health

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-05-22
• Study Completion: 2021-09-12
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

•Critically ill adult patients aged equal to or greater than 18 years
•Commenced on V-A ECMO for any reason
•Expected to require mechanical ventilation for at least 48 hours from initiation of ECMO
•Expected to remain in the ICU and on ECMO for at least 48 hours

Exclusion Criteria

•Patients with a poor prognosis where death is imminent in the subsequent 24 hours
•Participation in the study is not in the interest of the patient in the opinion of the treating physician

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Feasibility of completing energy expenditure measurements within 72 hours of ECMO commencement measured using blood gas measurements across the external membrane in addition to conventional indirect calorimetry. <br><br>Feasibility will be measured by prospectively collecting data on whether the energy expenditure measurement could or could not be completed. Real-time data during testing, indirect calorimetry data including measurement contraindications, reasons for non-completion are obtained. In addition, the bedside chart and medical records are consulted for physiologic and demographic data. [Within 72 hours of ECMO commencement]

Secondary Outcome Measures

Name	Time	Method
Feasibility of completing energy expenditure measurements on day seven following ECMO commencement. <br><br>Feasibility will be measured by prospectively collecting data on whether the energy expenditure measurement could or could not be completed. Real-time data during testing, indirect calorimetry data including measurement contraindications, reasons for non-completion are obtained. In addition, the bedside chart and medical records are consulted for physiologic and demographic data. [On day seven following ECMO commencement];Energy deficit compared to measured and predicted energy expenditure will be determined from hospital records.[oWithin 72 hours of ECMO commencement <br>oOn day seven of ECMO commencement <br>]