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Clinical Trials/NL-OMON44982
NL-OMON44982
Completed
Not Applicable

nravelling aetiology and risk factors in patients with a Bicuspid Aortic Valves * study of clinical outcome and genetics - BAV

Erasmus MC, Universitair Medisch Centrum Rotterdam0 sites220 target enrollmentTBD
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Conditionsbicuspid aortic valveturner syndrome10007510

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
bicuspid aortic valve
Sponsor
Erasmus MC, Universitair Medisch Centrum Rotterdam
Enrollment
220
Status
Completed
Last Updated
last year
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
TBD
Last Updated
last year
Study Type
Observational invasive

Investigators

Eligibility Criteria

Inclusion Criteria

  • •The study population consist of 100 adults with \*high\-risk\* BAV and 100 patients with Turner syndrome, who regularly seen at the outpatient clinic of the three academic hospitals (Erasmus MC, RadboudUMC and LUMC). ;Inclusion criteria
  • •In order to be eligible to participate in this study, a subject must meet all of the following criteria:
  • •\* Men and women aged \> 18 years;
  • •\* Capable of understanding and signing informed consent. ;Inclusion criteria for \*high\-risk\* BAV patients are:
  • •No prior aortic valve surgery, but with 1 or more of the following risk factors:
  • •\* Aortic stenosis: gradient \>3 m/sec
  • •\* Aortic regurgitation at least moderate
  • •\* Aortic aneurysm: \>40 mm ascending aorta and/or aortic index \> 2\.1;Inclusion criteria for patients with Turner syndrome:
  • •\* Know with chromosoom XO ;In addition, 20 healthy participants will be included who will receive echocardiography once at baseline.

Exclusion Criteria

  • •A potential subject who meets any of the following criteria will be excluded from participation in this study:
  • •Subjects who have any of the conditions below at the time of the enrollment or
  • •scan session are excluded from this study. Further, should it be determined by study staff that an enrolled subject meets any of the conditions below during the course of the study, the subject will be removed from the study.
  • •\* Contra\-indication to radiation exposure (CT/MRI): pregnancy
  • •\* Contra\-indication to iodine contrast media: renal failure, iodine
  • •\* Any contraindication to an MRI scan or gadolinium contrast media (renal failure,

Outcomes

Primary Outcomes

Not specified

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