nravelling aetiology and risk factors in patients with a Bicuspid Aortic Valves * study of clinical outcome and genetics - BAV

Erasmus MC, Universitair Medisch Centrum Rotterdam0 个研究点目标入组 220 人开始时间: 待定最近更新: 2024年7月22日

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•The study population consist of 100 adults with *high-risk* BAV and 100 patients with Turner syndrome, who regularly seen at the outpatient clinic of the three academic hospitals (Erasmus MC, RadboudUMC and LUMC). ;Inclusion criteria
•In order to be eligible to participate in this study, a subject must meet all of the following criteria:
•* Men and women aged > 18 years;
•* Capable of understanding and signing informed consent. ;Inclusion criteria for *high-risk* BAV patients are:
•No prior aortic valve surgery, but with 1 or more of the following risk factors:
•* Aortic stenosis: gradient >3 m/sec
•* Aortic regurgitation at least moderate
•* Aortic aneurysm: >40 mm ascending aorta and/or aortic index > 2.1;Inclusion criteria for patients with Turner syndrome:
•* Know with chromosoom XO ;In addition, 20 healthy participants will be included who will receive echocardiography once at baseline.

•A potential subject who meets any of the following criteria will be excluded from participation in this study:
•Subjects who have any of the conditions below at the time of the enrollment or
•scan session are excluded from this study. Further, should it be determined by study staff that an enrolled subject meets any of the conditions below during the course of the study, the subject will be removed from the study.
•* Contra-indication to radiation exposure (CT/MRI): pregnancy
•* Contra-indication to iodine contrast media: renal failure, iodine
•* Any contraindication to an MRI scan or gadolinium contrast media (renal failure,

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