JPRN-jRCT1031210030招募中2 期
Beta-Blocker Withdrawal in Heart Failure with Preserved Ejection Fraction and Chronotropic Incompetence (BRILLIANT): A Multicenter, Prospective, Randomized, Open-Label, Blinded Endpoint (PROBE) Trial - BRILLIANT trial
Obokata Masaru0 个研究点目标入组 150 人开始时间: 2021年4月9日最近更新:
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 发起方
- 入组人数
- 150
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- >= 20age old 至 ot applicable（—）
- 性别
- All
入选标准
- •1) Age equal to or more than 20 years old
- •2) Patients with established HFpEF or subjects who are suspected of HFpEF
- •3) Subjects who are treated with a pre-specified minimum dose of beta-blockers
- •5) Subjects who are able to keep cycle ergometry
- •exercise (0 watts) for more than 30 seconds
- •6) Patients who give written consent to participate in this study
排除标准
- •1) Patients with mimic HFpEF:
- •More than mild aortic or mitral valve stenosis, more than moderate aortic or mitral valve regurgitation, history of left ventricular ejection fraction less than 40%, non-group II pulmonary hypertension, hypertrophic cardiomyopathy, cardiac sarcoidosis, constrictive pericardititis
- •2) Patients with comorbidities contraindicated for exercise testing:
- •acute decompensated heart failure, acute coronary syndrome, severe coronary artery disease
- •3) Patients who are expected to have disadvantages in discontinuing beta-blockers:
- •History of old myocardial infarction, presence of obvious myocardial ischemia, appearance of new wall motion abnormality during exercise, history of hospitalization due to tachyarrhythmia within 6 months, Basedow's disease
- •4) Patients who cannot exercise their legs due to
- •abnormalities in joints, muscles, etc.
- •4) Patients who are judged to be unsuitable for th
- •e study by the investigators
研究者
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