Clinical Trials/NCT03204032

NCT03204032

Unknown

Phase 2

A Phase II Randomized,Controlled,Open Label,Multicentre Study of Tegafur Combined With Temozolomide Versus Tegafur Combined With Temozolomide and Thalidomide in Subjects With Advanced Extrapancreatic Neuroendocrine Tumor

Chinese Academy of Medical Sciences1 site in 1 country60 target enrollmentOctober 2016

ConditionsExtrapancreatic Neuroendocrine Tumor

InterventionsTemozolomide Tegafur Thalidomide

DrugsTegafur Temozolomide Thalidomide

Overview

Phase: Phase 2
Intervention: Temozolomide
Conditions: Extrapancreatic Neuroendocrine Tumor
Sponsor: Chinese Academy of Medical Sciences
Enrollment: 60
Locations: 1
Primary Endpoint: Objective Response Rate(ORR)
Last Updated: 8 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

A Phase II Randomized,Controlled,Open Label,Multicentre Study to evaluate the efficacy and safety of Tegafur combined with Temozolomide versus Tegafur combined with Temozolomide and Thalidomide in subjects with Advanced Extrapancreatic Neuroendocrine Tumor

Registry

clinicaltrials.gov

Start Date

October 2016

End Date

September 2018

Last Updated

8 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Chinese Academy of Medical Sciences

Responsible Party

Principal Investigator

yihebali chi

Assistant Professor

Chinese Academy of Medical Sciences

Eligibility Criteria

Inclusion Criteria

•Patients should participate in the study voluntarily and sign informed consent;
•Histopathological proven diagnosis of low and intermediate grade (G1, G2 or G3) advanced Extrapancreatic neuroendocrine tumor( locally advanced, unresectable or distant Metastatic). For gastroenteropancreatic neuroendocrine tumor（GEP-NET）,the
•Page 4 of 5 \[DRAFT\] - classification is based on nuclear mitotic number and the Ki-67 index,which are as follows:G1:Nuclear mitotic number \<2/10HPF,Ki-67 proliferative index ≤2%.G2: Nuclear mitotic number 2～20/10HPF,Ki-67 proliferative index 3%～20%.G3 Nuclear mitotic number \> 20/10HPF,Ki-67 proliferative index \>20%;
•Patients with advanced Extrapancreatic neuroendocrine tumor who had not been treated or had no more than two kinds of Systemic Anti-tumor Therapy,which could be somatostatin analogs, interferon, PRRT (peptide receptor radionuclide therapy), mTOR inhibitors, or chemotherapy (without any use of azole amines, fluorouracil,or thalidomide chemotherapy drugs);
•Radiological documentation of tumor progression is required within 12months prior to randomization;
•At least one measurable lesion (byRECIST1.1);
•ANC≥1.5×109/L,PLT≥100×109/L,HB≥90g/L,TBIL≤1.5ULN ;Without supportive care, ALT≤2.5ULN and ALP≤2.5ULN (without hepatic metastasis) ALT≤5ULN and ALP≤5ULN(with hepatic metastasis);serum creatin ≤1.5ULN and creatinine clearance rate
•≥60ml/min；INR≤1.5ULN and APTT ≤1.5ULN ;
•ECOG PS:0-1;
•Life expectancy of more than 12 weeks;

Exclusion Criteria

•1、Diagnosed with high grade (G3) neuroendocrine carcinomas, adenocarcinoma, pancreatic islet cell carcinoma, goblet cell carcinoid, large cell neuroendocrine carcinoma, and small cell carcinoma; 2、Functional NET which needs concomiant use of long-acting somatostatin analogues to control symptoms such as insulinoma, gastrinoma, glucagon tumor, somatostatin, ACTH tumor, VIP tumor, and carcinoid syndrome, Zollinger-Ellison syndrome or other disease-specific active symptoms.
•3、Have received anti-vascular endothelial growth factor（VEGF）/VEGFR targeted drugs and progressed upon these drugs 4、Urinalysis shows urine protein ≥ 2+ or 24-hour protein quantity test shows urinary protein ≥1 g; 5、Serum potassium, calcium (albumin-bound ionic or corrected) or magnesium exceed the normal range with clinical significance； 6、Under anti-hypertension treatment, still uncontrolled hypertension, defined as: systolic blood pressure \>140 mmHg or diastolic blood pressure \>90 mmHg; 7、Gastrointestinal disease or condition that investigators suspect may affect drug absorption, including, but not limited to, active gastric and duodenal ulcers, ulcerative colitis and other digestive disease, gastrointestinal tumor with active bleeding, or other gastrointestinal conditions that may cause bleeding or perforation by investigator's discretion; 8、History or presence of a serious hemorrhage (\>30 ml within 3 months), hemoptysis (\>5 ml blood within 4 weeks) or a thromboembolic event (including transient ischemic attack) within 12 months; 9、Clinically significant cardiovascular disease, including but not limited to, acute myocardial infarction within 6 months prior to enrollment, severe/unstable angina pectoris or coronary artery bypass grafting, congestive heart failure according to the New York Heart Association (NYHA) classification ≥ 2; ventricular arrhythmias which needs drug treatment; LVEF (LVEF) \<50%; 10、Mean corrected QT interval (QTc) ≥ 480 msec; 11、Other malignancies diagnosed within the previous 5 years, except basal cell carcinoma or cervical carcinoma in situ after radical resection; 12、Anti-tumor therapy received within 4 weeks prior to the initiation of the investigational treatment, including, but not limited to, chemotherapy, radical radiotherapy, targeted therapy, immunotherapy and anti-tumor Chinese medicine treatment, hepatic chemoembolization, cryoablation and radiofrequency ablation ; 13、Palliative radiotherapy for a bone metastasis lesion within 2 weeks prior to the initiation of the investigational treatment; 14、Any clinically significant active infection, including, but not limited to, human immunodeficiency virus (HIV) infection; 15、History of clinically significant hepatic disease, including, but not limited to, known hepatitis B virus (HBV) infection with HBV DNA positive (copies ≥1×104/ml); known Hepatitis C virus （HCV) infection with HCV RNA positive (copies ≥1×103/m); or liver cirrhosis, etc.
•16、Surgery (except biopsy) within 28 days prior to the initiation of investigational treatment or unhealed surgical incision; 17、Brain metastases and/or spinal cord compression not treated by surgery and/or radiotherapy, and with no clinical imaging evidence of disease stability; 18、Toxicity from a previous anti-tumor treatment that does not return to Grade 0 or 1 (except for hair loss);
•19、Received investigational treatments in other clinical studies within 4 weeks prior to enrollment; 20、Women who are pregnant or lactating; 21、Other disease, metabolic disorder, physical examination anomaly, abnormal laboratory result, or any other conditions are inappropriate for the use of the investigational product or affect interpretation of study results.

Arms & Interventions

Tegafur and Temozolomide combined with Thalidomide

Intervention: Temozolomide

Tegafur and Temozolomide

Intervention: Tegafur

Tegafur and Temozolomide

Intervention: Temozolomide

Tegafur and Temozolomide combined with Thalidomide

Intervention: Tegafur

Tegafur and Temozolomide combined with Thalidomide

Intervention: Thalidomide

Outcomes

Primary Outcomes

Objective Response Rate(ORR)

Time Frame: From randomization，each 6 weeks or 12 weeks(a year later) up to intolerance to the toxicity or PD (up to 24 months)

Secondary Outcomes

Progression free survival(PFS)(From randomization，each 6 weeks or 12 weeks(a year later)(a year later) up to PD or death (up to 24 months))
Duration of Response(DOR)(From randomization，each 6 weeks or 12 weeks(a year later) up to PD or death(up to 24 months))
Disease Control Rate(DCR)(From randomization，each 6 weeks or 12 weeks(a year later) up to intolerable toxicity or PD (up to 24 months))
Time to Tumor Response (TTR)(From randomization，each 6 weeks or 12 weeks(a year later)up to PD or death(up to 24 months))