Childhood Cancer Survivor Study
- Conditions
- Cancer
- Registration Number
- NCT01120353
- Lead Sponsor
- St. Jude Children's Research Hospital
- Brief Summary
The Childhood Cancer Survivor Study (CCSS) will investigate the long-term effects of cancer and its associated therapies. A retrospective cohort study will be conducted through a multi-institutional collaboration, which will involve the identification and active follow-up of a cohort of approximately 50,000 survivors of cancer, diagnosed before 21 years of age, between 1970 and 1999 and 10,000 sibling controls. This project will study children and young adults exposed to specific therapeutic modalities, including radiation, chemotherapy, and/or surgery, who are at increased risk of late-occurring adverse health outcomes. A group of sibling controls will be identified and data collected for comparison purposes.
- Detailed Description
The study will focus on the following objectives:
* Characterize survivors' health with respect to disease- and treatment-related factors.
* Investigate the consequences of various intensities of exposure to chemotherapy and/or radiation on health outcomes (e.g., cardiovascular, reproductive, second cancers, etc...).
* Compare the mortality experience of survivors with the general population.
* Characterize the health-related behaviors, patterns of medical care, and medical follow-up needs of survivors.
* Describe patterns of familial aggregation of cancer, including known (and variations of) cancer family syndromes.
* Collect and store biologic samples (saliva, blood, second tumor tissue) to correlate with health outcomes and use for future research.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 50000
Initial Cohort:
- Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor, Wilms tumor, neuroblastoma, or soft tissue sarcoma before age 21 years between January 1, 1970 and December 31, 1986 at one of participating centers.
Expanded cohort:
- Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor, kidney tumor, neuroblastoma, or rhabdomyosarcoma before age 21 years between January 1, 1987 and December 31, 1999 at one of participating centers.
- English- or Spanish-speaking and living in the U.S. or Canada at the time of diagnosis.
- Diagnosis of non-malignant tumors (i.e., Langerhans cell histiocytosis, meningioma, craniopharyngioma, etc.) treated with radiation and/or chemotherapy.
- Non-English speaking or residence outside the US or Canada.
Sibling Controls:
- For comparison purposes, a group of sibling controls will be identified to represent a stratified random sample based on the distribution of survivors with regard to cancer diagnosis, age, sex, race, and geographic location.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To characterize survivors' health outcomes with respect to disease-, treatment, and genetic-related factors. 25 years
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (31)
Children's Hospital Los Angeles
🇺🇸Los Angeles, California, United States
Ana & Robert H. Lurie Children's Hospital of Chicago
🇺🇸Chicago, Illinois, United States
Nationwide Children's Hospital
🇺🇸Columbus, Ohio, United States
Children's Hospital of Pittsburgh
🇺🇸Pittsburgh, Pennsylvania, United States
Dana-Farber Cancer Institute
🇺🇸Boston, Massachusetts, United States
Texas Children's Hospital
🇺🇸Houston, Texas, United States
Seattle Children's Hospital
🇺🇸Seattle, Washington, United States
Children's Hospitals & Clinics of Minnesota
🇺🇸Minneapolis, Minnesota, United States
University of Minnesota
🇺🇸Minneapolis, Minnesota, United States
Children's Hospital of Philadelphia
🇺🇸Philadelphia, Pennsylvania, United States
Children's National Medical Center
🇺🇸Washington, District of Columbia, United States
City of Hope National Medical Center
🇺🇸Duarte, California, United States
St. Louis Children's Hospital/The Washington University
🇺🇸Saint Louis, Missouri, United States
The Hospital for Sick Children
🇨🇦Toronto, Ontario, Canada
University of Michigan/Mott Children's Hospital
🇺🇸Ann Arbor, Michigan, United States
Roswell Park Cancer Institute
🇺🇸Buffalo, New York, United States
Children's Hospital of Orange County
🇺🇸Orange, California, United States
Emory University/Children's Health Care of Atlanta
🇺🇸Atlanta, Georgia, United States
Cook Children's Medical Center
🇺🇸Fort Worth, Texas, United States
Stanford University School of Medicine
🇺🇸Stanford, California, United States
St. Jude Children's Research Hospital
🇺🇸Memphis, Tennessee, United States
University of Chicago
🇺🇸Chicago, Illinois, United States
University of California-Los Angeles
🇺🇸Los Angeles, California, United States
Memorial-Sloan Kettering Cancer Center
🇺🇸New York, New York, United States
Indiana University/Riley Hospital for Children
🇺🇸Indianapolis, Indiana, United States
M.D. Anderson Cancer Center
🇺🇸Houston, Texas, United States
University of Texas Southwestern Medical Center
🇺🇸Dallas, Texas, United States
University of Alabama at Birmingham/Children's of Alabama
🇺🇸Birmingham, Alabama, United States
University of California-San Francisco
🇺🇸San Francisco, California, United States
Mayo Clinic
🇺🇸Rochester, Minnesota, United States
Children's Hospital Colorado
🇺🇸Aurora, Colorado, United States