NCT07525635招募中1 期
Aspirin Dosing and Platelet Phenotype in Pregnancy
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Measures of platelet aggregation assessed by Light Transmission Aggregometry (LTA)
研究概览
简要总结
The purpose of this study is assess platelet phenotypes based on aspirin dosing in pregnant patients at risk for the development preeclampsia who are taking 81mg twice a day aspirin. Blood samples will be collected approximately 4 weeks after initiation of aspirin to evaluate the platelet phenotype during pregnancy in patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Pregnant people prior to 17 weeks
- •Prenatal care at NYU Langone Health Obstetrics and Gynecology Associates
- •Age 18-50 years
- •Singleton viable gestation
- •Pregnant patients at high risk of preeclampsia: Patients meeting USPSTF recommendation for aspirin prophylaxis for preeclampsia based on clinical risk factors.
排除标准
- •Undergoing glucose challenge test (GCT) at time of blood draw
- •Allergy or intolerance to aspirin
- •Antithrombotic or antiplatelet therapy
- •Anemia (hemoglobin <10 g/dl) or thrombocytopenia (platelet count <100,000), or thrombocytosis (platelet count >600,000)
- •Known hemorrhagic diathesis
- •Planned delivery outside of NYU
研究组 & 干预措施
Twice daily dosing of Aspirin
Experimental
Participants will take 81mg Aspirin orally, twice daily (162mg total) for 4 weeks and then return to the dosing regimen as prescribed by the discretion of their treating physician.
干预措施: Aspirin (Drug)
结局指标
主要结局
Measures of platelet aggregation assessed by Light Transmission Aggregometry (LTA)
时间窗: Baseline, 4 weeks after initiation of aspirin
次要结局
- Change in serum thromboxane(Baseline, 4 weeks after initiation of aspirin)
- Change in complete blood count(Baseline, 4 weeks after initiation of aspirin)
- Change in Mean Platelet Volume (MPV)(Baseline, 4 weeks after initiation of aspirin)
- Change in Platelet Distribution Width (PDW)(Baseline, 4 weeks after initiation of aspirin)
- Change in Plateletcrit (PCT)(Baseline, 4 weeks after initiation of aspirin)
- Change in Life's Essential 8 questionnaire(Baseline, 4 weeks after initiation of aspirin)
研究者
研究点 (1)
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