Comparison of two weight loss programs involving 16 weeks on a severely energy-restricted diet in adults with overweight or obesity: The TANGO Diet Trial (Temporary phases of Accelerated weight loss for Noticeably Greater Outcomes)
- Conditions
- obesityoverweightcardiovascular diseaseosteoporosissarcopeniabinge eatingmood disordersDiet and Nutrition - ObesityDiet and Nutrition - Other diet and nutrition disordersCardiovascular - Coronary heart disease
- Registration Number
- ACTRN12623000338662
- Lead Sponsor
- The University of Western Australia
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Active, not recruiting
- Sex
- All
- Target Recruitment
- 304
18-70 years of age
Body mass index (BMI) equal to or greater than 30 kg/m2 or BMI equal to or greater than 27 kg/m2 if disease risk factors and/or obesity-related comorbidities are present
Able to attend our facility 17 times over the 104-week (24-month) clinical trial (15 times in the first 53 weeks (12 months)
Weight stable for at least 1 month (± 2 kg) before commencement of the severe diet
Living in the Perth metropolitan area
Able to understand written and spoken English
Have access to an email account
Have access to a computer (either a smartphone, laptop or desktop) and the Internet
Type 1 diabetes
Pregnancy (or breastfeeding)
Pregnancy planned in the next 2 years
Schizophrenia
Diagnosed eating disorder
A score on the Alcohol Use Disorders Identification Test – Consumption (AUDIT-C) of equal to or greater than 6 (for female adults) or equal to or greater than 7 (for male adults)
Unwillingness to abstain from the consumption of alcohol during the 16-week severe diet
Use within the past 6 months of any illegal or recreational drugs
Severe/advanced kidney disease
Severe/advanced liver disease
Porphyria
Recent myocardial infarction (3 months)
Recent cerebrovascular event (3 months)
Recent commencement of anticoagulant (e.g., warfarin) treatment (3 months)
Current fluid restriction treatment
Unstable angina
Lactose intolerance
Strict veganism
Unwillingness to consume the meal replacement products to be provided by the research trial for 16 weeks
Previous bariatric surgery
Bariatric surgery planned in the next 2 years
Recent involvement in another clinical trial (3 months)
Involvement in another clinical trial planned in the next 2 years
Tobacco or vape use in the past 6 months
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method