Effect of Hyperthyroidism on Bone Mineral density, Bone turnover markers and fracture risk before and after treatment
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 130
- 试验地点
- 1
- 主要终点
- 1.to comapre BMD, bone turnover markers, fracture risk of newly diagnosed hyperthyroid patients with
研究概览
简要总结
ØTo compare the BMD status in hyperthyroid patients with control group at baseline and to see the effect of antithyroid treatment on BMD at 1 year of therapy in hyperthyroid patients.
ØTo compare the levels of Sr. P1NP ,CTX in Hyperthyroid patients with control group at baseline.
ØTo see the effect of antithyroid treatment on levels of Sr. P1NP and CTX after achievement of normal thyroid status for 3 months in hyperthyroid patients.
ØTo look for the fracture risk in hyperthyroid patients and to see the effect of antithyroid treatment on fracture risk at 1 year of therapy.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •premenopausal females and males aged 18–65 years, with newly detected hyperthyroidism were included in this study.
- •The patients with hyperthyroidism had a diagnosis of Graves disease, Toxic MNG or Toxic adenoma.
- •There were also age, sex, BMI matched healthy control groups who were euthyroid.
排除标准
- 未提供
结局指标
主要结局
1.to comapre BMD, bone turnover markers, fracture risk of newly diagnosed hyperthyroid patients with
时间窗: 1.at baseline , | 2. after 3 months of euthyroid state | 3. 1 year after treatment for BMD and fracture risk
control
时间窗: 1.at baseline , | 2. after 3 months of euthyroid state | 3. 1 year after treatment for BMD and fracture risk
2. to compare the change in bone turnover markers after treatment with baseline
时间窗: 1.at baseline , | 2. after 3 months of euthyroid state | 3. 1 year after treatment for BMD and fracture risk
3. to compare the change in BMD, fracture risk after treatment with baseline
时间窗: 1.at baseline , | 2. after 3 months of euthyroid state | 3. 1 year after treatment for BMD and fracture risk
次要结局
- correlation of thyroid hormones with bone turnover markers at baseline(at baseline before treatment)
研究者
BHABANI SANKAR DHAL
MKCG medical college