Optimising Steroid Replacement in Patients With Adrenal Insufficiency
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Global corticosteroid metabolism
研究概览
简要总结
Adrenal insufficiency is a condition where the adrenal glands do not produce an adequate amount of steroid hormones. The aetiology of adrenal insufficiency can be primary or secondary. Patients will adrenal insufficiency have increased morbidity and mortality. In recent years there has been concern regarding what is the optimal dose and regimen of steroid replacement for patients. Unfortunately there is no accurate way of monitoring if a patient is on too much or too little steroid. We have shown in hypopituitary patients with secondary adrenal insufficiency that higher doses of hydrocortisone may be harmful. This reason for this is not fully understood.
In recent years, a modified release hydrocortisone tablet (Plenadren) taken once per day (unlike conventional immediate release hydrocortisone which requires twice or thrice daily regimen) has come on the market. This tablet has shown to a have a steroid profile that more closely resembles normal physiology, avoiding the peak steroid levels that occur during thrice daily regimens, which may be of importance for improving outcome in adrenal insufficiency patients. It also shown improved cardiovascular risk factors, glucose metabolism and quality of life in compared to conventional treatment.
The aim of our study is to assess the effect of hydrocortisone therapy on how the body uses and breaks down (metabolises) steroids. This will be done by several different research methods: by measuring markers of steroid action and metabolism in blood, urine and within the fat tissue under the skin in the abdomen. These results will be compared in the same patient while on their usual hydrocortisone and after switching to modified release hydrocortisone for 12 weeks, and to results from a normal healthy control group who are not on steroid replacement.
This will be the first study to assess the impact of this new modified release hydrocortisone in relation to tissue steroid metabolism. The results will potentially help us to improve the treatment of patients with steroid deficiency and reduce the side effects seen in these patients.
详细描述
This is a prospective, cross-over study. This study cannot be blinded or placebo controlled due to the risk of adrenal crisis in the study population with primary and secondary adrenal insufficiency.
The aim of study is to assess the effect of immediate release and modified release hydrocortisone therapy on corticosteroid metabolism and 11-HSD1 in vivo (by assessment of urine metabolites and liver/ adipose tissue metabolism) by using several translational research approaches. This will also be compared to normal healthy controls to assess which treatment protocol is most physiological.
Study Objectives
- To assess the effect of changing to modified release hydrocortisone therapy on global corticosteroid metabolism as assessed by urinary steroid metabolite profiles.
- To assess the effect of changing to modified release hydrocortisone therapy on adipose tissue corticosteroid metabolism and action
- To assess the effect of changing to modified release hydrocortisone on hepatic corticosteroid metabolism.
- To assess the effect of changing to modified release hydrocortisone therapy on patient quality of life (QoL) as assessed through validated QoL questionnaires.
- To compare results to normal healthy controls to assess which treatment protocol is most physiological.
- To assess potential biomarkers for adequacy of hydrocortisone replacement therapy.
Patients will switch from their usual conventional immediate release hydrocortisone to daily dose equivalent of modified release hydrocortisone (Plenadren®) for 12 weeks.Other hormone replacement therapy regimens will not be adjusted during the study period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female patients ≥ 18years of age with Primary Adrenal Insufficiency (Addison's disease) confirmed on biochemical testing.
- •Male or female patients ≥ 18years of age with ACTH deficiency defined by a stimulated peak cortisol in response to insulin-induced hypoglycaemia or short synacthen testing <400 nmol/l, with known organic pituitary disease, and no adjustment in hormone replacement for at least 3 months prior to study entry.
- •Signed informed consent to participate in the study
排除标准
- •Age < 18 years
- •Patients with acute medical or surgical illness
- •Patients with advanced cardiac/pulmonary disease
- •Patients with a terminal illness
- •Patients on glucocorticoids for purposes other than ACTH deficiency
- •Patients on agents that interfere with corticosteroid metabolism
研究组 & 干预措施
Modified release Hydrocortisone
12 weeks of modified release hydrocortisone (Plenadren)
干预措施: Modified release hydrocortisone (Drug)
结局指标
主要结局
Global corticosteroid metabolism
时间窗: At baseline and after 12 weeks of Plenadren(intervention) treatment
Urinary steroid metabolite profiles.
Adipose tissue corticosteroid metabolism
时间窗: At baseline and after 12 weeks of Plenadren(intervention) treatment
Cortisol generation profile using adipose tissue microdialysis catheter
Hepatic corticosteroid metabolism
时间窗: At baseline and after 12 weeks of Plenadren(intervention) treatment
Serum Cortisol generation profile
次要结局
- Potential biomarkers for adequacy of hydrocortisone replacement(At baseline and after 12 weeks of Plenadren(intervention) treatment)
- Quality of Life questionnaires(At baseline and after 12 weeks of Plenadren(intervention) treatment)
研究者
Dr Mark Sherlock
Consultant Endocrinologist
The Adelaide and Meath Hospital, incorporating The National Children's Hospital