Acetaminophen and Chlorpheniramine Maleate Premedication in Chronically Transfused Patients: A Prospective, Randomized Controlled Trial
- Conditions
- Efficacy of chlorpheniramine maleate and acetaminophen premedication in prevent febrile nonhemolytic transfusion reaction in chronically transfused patient.chronically transfused patientpremedicationfebrile nonhemolytic transfusion reaction
- Registration Number
- TCTR20221011002
- Lead Sponsor
- Supanat Janyangam
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 94
1. Patient receiving red cell transfusion at least 2 unit from the same cause in the last 3 months
2. Hemoglobin level before transfusion is below 8 gm/dL
3. At least 18 years of age
1. Patient receiving red cell transfusion from acute blood loss
2. Patient receiving red cell transfusion related to trauma
3. Patient receiving red cell transfusion related to surgery
4. History of febrile illness following transfusion in the last 3 months
5. History of allergic reaction following transfusion in the last 3 months
6. Acetaminophen allergy
7. Chlorpheniramine maleate allergy
8. Febrile illness within 24 hours prior to transfusion
9. Allergic reaction within 24 hours prior to transfusion
10. Patient receiving acetaminophen, chlorpheniramine maleate, other antihistamine, or corticosteroid equivalent to 5mg of prednisolone within 48 hours prior to transfusion
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of febrile nonhemolytic transfusion reaction and allergic transfusion reaction after received acetaminophen and chlorpheniramine maleate premedication before LPRC transfusion within 24 hours after transfusion vital signs and clinical during transfusion, self-recorded body temperature and clinical after transfusion
- Secondary Outcome Measures
Name Time Method