JPRN-UMIN000010323已完成未知
A study to evaluate the effect of ezetimibe and rosuvastatin on intravascular ultrasound-derived coronary atheroma and lipid lowering effect. - Mie study of Ezetimibe and Rosvastatin for attenuation of coronary artery atherosclerosis by using Intravascular ultrasound (MERIT study)
Department of Cardiology and Nephrology, Mie University Graduate School of Medicine0 个研究点目标入组 50 人开始时间: 2013年3月27日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 50
研究概览
简要总结
Intensive lipid-lowering therapy with ezetimibe provide greater reduction in the percent change in plaque volume (PV), the primary endpoint, than the statin monotherapy group (-13.2% versus -3.1%, respectively, P = 0.050).Moreover, percent change in PV showed positive correlations with percent change of LDL-C (r = 0.384, P = 0.015). Intensive lipid-lowering therapy with ezetimibe added to usual-dose statin may provide significant incremental reduction in coronary plaques compared with usual-dose statin monotherapy.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 20years-old 至 ot applicable（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1, privious allergy for ezetimibe or any of statins 2, contraindication for rosuvastatin and already recieved rosuvastatin 3, secondary dyslipidemia 4, history of acute coronary syndrome within 3months before study entry 5, congestive heart failure (NYHA 3 or 4) 6, low left ventricular contractility 7, inducation for coronary artery bypass graft 8, poor control HTN patient (systolic BP over 220mmHg, diastolic BP over 110mmHg) 9, poor control diabetic patient (HbA1c over 9.5%) 10, hemodialysis patient 11, severe renal dysfunction (30 over CCr or serum Cre over 2.0) 12, serum CK over 300 13, severe liver dysfunction
研究者
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