Nonrelapsing Secondary Progressive Multiple Sclerosis (NRSPMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168)
- Conditions
- Secondary Progressive Multiple Sclerosis
- Interventions
- Drug: Placebo to match Tolebrutinib
- Registration Number
- NCT04411641
- Lead Sponsor
- Sanofi
- Brief Summary
Primary Objective:
To determine the efficacy of SAR442168 compared to placebo in delaying disability progression in NRSPMS
Secondary Objective:
To evaluate efficacy of SAR442168 compared to placebo on clinical endpoints, magnetic resonance imaging (MRI) lesions, cognitive performance, physical function, and quality of life To evaluate safety and tolerability of SAR442168 To evaluate population pharmacokinetics (PK) of SAR442168 and relevant metabolites in NRSPMS and its relationship to efficacy and safety To evaluate pharmacodynamics (PD) of SAR442168
- Detailed Description
Study duration will vary per participant in this event driven trial with a treatment duration of approximately 24 to 48 months.
Participants completing the treatment period will be proposed to enroll in a separate long term safety study.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1131
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo to match Tolebrutinib Placebo tablet to match SAR442168 once daily SAR442168 Tolebrutinib Dose 1 of oral SAR442168 once daily
- Primary Outcome Measures
Name Time Method 6-month confirmed disability progression (CDP) Up to 48 approximately months Time to onset of 6 months CDP defined as follows:
-Increase of ≥1.0 point from the baseline expanded disability status scale (EDSS) score when the baseline score is ≤5.0, or -Increase of ≥0.5 point when the baseline EDSS score is \>5.0 -
- Secondary Outcome Measures
Name Time Method 3-month CDP Up to approximately 48 months Time to onset of 3-month CDP as assessed by EDSS score
New and enlarging T2 hyperintense lesions by MRI From Baseline up to approximately 48 months Total number of new or enlarging T2 hyperintense lesions as detected by MRI
3-months change in 9-HPT Up to approximately 48 months Time to onset of sustained 20% increase in the 9 hole peg test (9-HPT) for at least 3 months
3-months change in T25-FW Up to approximately 48 months Time to onset of sustained 20% increase in the T25-FW for at least 3 months
Time to onset of confirmed disability improvement (CDI) From Baseline up to approximately 48 months Time to CDI defined as ≥1.0 point decrease on the EDSS score from baseline confirmed over at least 6 months
Brain volume loss (BVL) From 6 Months up to approximately 48 months Percent change in Brain volume loss (BVL) as detected by brain MRI at the EOS compared to month 6
Change in cognitive function From Baseline up to approximately 48 months Change in cognitive function at the EOS compared to baseline as assessed by the Symbol Digit Modalities Test (SDMT) and by the California Verbal Learning Test (CVLT-II)
Change in Multiple Sclerosis Quality of Life-54 (MSQoL-54) From Baseline up to approximately 48 months Change in Multiple Sclerosis Quality of Life-54 (MSQoL-54) from the baseline through the EOS
Safety and Tolerability From Screening until end of study up to approximately 48 months Number of participants with adverse events (AEs), Serious AEs, AEs leading to permanent study intervention discontinuation, and adverse events of special interest (AESI)
Population pharmacokinetics Months 6, 9 and 12 Plasma concentration of SAR442168 and relevant metabolites (population PK assessment) at Months 6, 9, and 12
Change in plasma neurofilament light chain (NfL) From Baseline up to approximately 48 months Change in NfL levels at the EOS compared to baseline
Changes in serum Immunoglobulin level From Baseline up to approximately 48 months Changes in serum Immunoglobulin level at the EOS compared to baseline
Change in lymphocyte phenotype subsets From Baseline up to approximately 48 months Change in lymphocyte phenotype subsets in whole blood at the EOS compared to baseline in a subset of participants
Change in serum chitinase-3 like protein 1 (Chi3L1) From Baseline up to approximately 48 months Change in serum chitinase-3 like protein 1 (Chi3L1) at the EOS compared to baseline
Trial Locations
- Locations (306)
University of Alabama MS Center-Site Number:8400013
🇺🇸Birmingham, Alabama, United States
Center for Neurology and Spine-Site Number:8400089
🇺🇸Phoenix, Arizona, United States
Arcadia Neurology Center-Site Number:8400070
🇺🇸Arcadia, California, United States
UC San Diego ACTRI-Site Number:8400101
🇺🇸La Jolla, California, United States
Collaborative Neuroscience Research-Site Number:8400045
🇺🇸Long Beach, California, United States
Multiple Sclerosis Center-Site Number:8400143
🇺🇸Los Angeles, California, United States
University of San Francisco, Sandler Neurosciences Center-Site Number:8400137
🇺🇸San Francisco, California, United States
Harbor UCLA-Site Number:8400088
🇺🇸Torrance, California, United States
Regina Berkovich, MD, PhD-Site Number:8400059
🇺🇸West Hollywood, California, United States
Mountain Neurological Research Center, Inc.-Site Number:8400128
🇺🇸Basalt, Colorado, United States
University of Colorado-Site Number:8400012
🇺🇸Denver, Colorado, United States
Advanced Neurosciences Research-Site Number:8400025
🇺🇸Fort Collins, Colorado, United States
South Florida Neurology Associates-Site Number:8400029
🇺🇸Boca Raton, Florida, United States
Neurology Associates, PA-Site Number:8400004
🇺🇸Maitland, Florida, United States
Aqualane Clinical Research-Site Number:8400027
🇺🇸Naples, Florida, United States
Axiom Clinical Research of Florida-Site Number:8400001
🇺🇸Tampa, Florida, United States
University of South Florida-Site Number:8400006
🇺🇸Tampa, Florida, United States
Meridian Clinical Research-Site Number:8400003
🇺🇸Savannah, Georgia, United States
Consultants In Neurology-Site Number:8400011
🇺🇸Northbrook, Illinois, United States
University of Kansas Medical Center-Site Number:8400023
🇺🇸Kansas City, Kansas, United States
CHI Saint Joseph Medical Group Neurology-Site Number:8400110
🇺🇸Lexington, Kentucky, United States
Tufts Medical Center-Site Number:8400072
🇺🇸Boston, Massachusetts, United States
University of Massachusetts-Site Number:8400014
🇺🇸Worcester, Massachusetts, United States
Wayne State University-Site Number:8400046
🇺🇸Detroit, Michigan, United States
The Memorial Hospital-Site Number:8400033
🇺🇸Owosso, Michigan, United States
Minneapolis Clinic of Neurology-Site Number:8400051
🇺🇸Minneapolis, Minnesota, United States
Mayo Clinic-Site Number:8400111
🇺🇸Rochester, Minnesota, United States
Missouri Baptist Medical Center-Site Number:8400019
🇺🇸Saint Louis, Missouri, United States
Lou Ruvo Center for Brain Health-Site Number:8400117
🇺🇸Las Vegas, Nevada, United States
Holy Name Hospital-Site Number:8400104
🇺🇸Teaneck, New Jersey, United States
University of New Mexico-Site Number:8400032
🇺🇸Albuquerque, New Mexico, United States
Icahn School of Medicine at Mount Sinai (Department of Endoc-Site Number:8400038
🇺🇸New York, New York, United States
Neurology Associates of Stony Brook-Site Number:8400042
🇺🇸Stony Brook, New York, United States
Meridian Clinical Research, LLC-Site Number:8400005
🇺🇸Raleigh, North Carolina, United States
Sanford Brain & Spine Center-Site Number:8400126
🇺🇸Fargo, North Dakota, United States
University Hospitals CMC-Site Number:8400083
🇺🇸Cleveland, Ohio, United States
Cleveland Clinic-Site Number:8400125
🇺🇸Cleveland, Ohio, United States
Optimed Research, LTD-Site Number:8400147
🇺🇸Columbus, Ohio, United States
Neurology Specialists-Site Number:8400002
🇺🇸Dayton, Ohio, United States
Columbus Neuroscience-Site Number:8400010
🇺🇸Westerville, Ohio, United States
Providence Multiple Sclerosis Center-Site Number:8400020
🇺🇸Portland, Oregon, United States
Perelman Center for Advanced Medicine-Site Number:8400142
🇺🇸Philadelphia, Pennsylvania, United States
Jefferson Neurology Associates-Site Number:8400016
🇺🇸Philadelphia, Pennsylvania, United States
Premier Neurology-Site Number:8400069
🇺🇸Greer, South Carolina, United States
Mountain View Clinical Research-Site Number:8400024
🇺🇸Greer, South Carolina, United States
Neurology Clinic, PC-Site Number:8400087
🇺🇸Cordova, Tennessee, United States
Advanced Neuroscience Center-Site Number:8400035
🇺🇸Franklin, Tennessee, United States
Baylor College of Medicine-Site Number:8400136
🇺🇸Houston, Texas, United States
Neurology Center of San Antonio-Site Number:8400036
🇺🇸San Antonio, Texas, United States
University Of Vermont College Of Medicine-Site Number:8400130
🇺🇸Burlington, Vermont, United States
Medical College of Wisconsin-Site Number:8400028
🇺🇸Milwaukee, Wisconsin, United States
Investigational Site Number :0320002
🇦🇷Capital Federal, Buenos Aires, Argentina
Investigational Site Number :0320001
🇦🇷Caba, Ciudad De Buenos Aires, Argentina
Investigational Site Number :0320007
🇦🇷Buenos Aires, Argentina
Investigational Site Number :0320006
🇦🇷Córdoba, Argentina
Investigational Site Number :0320005
🇦🇷San Miguel de Tucuman, Argentina
Investigational Site Number : 0360007
🇦🇺St Leonards, New South Wales, Australia
Investigational Site Number :0360003
🇦🇺Woolloongabba, Queensland, Australia
Investigational Site Number :0360002
🇦🇺Kent Town, South Australia, Australia
Investigational Site Number :0360004
🇦🇺Hobart, Tasmania, Australia
Investigational Site Number :0360001
🇦🇺Fitzroy, Victoria, Australia
Investigational Site Number :0360006
🇦🇺Heidelberg West, Victoria, Australia
Investigational Site Number :0400003
🇦🇹Innsbruck, Austria
Investigational Site Number :0400001
🇦🇹Linz, Austria
Investigational Site Number :0400004
🇦🇹Linz, Austria
Investigational Site Number :0400002
🇦🇹Wien, Austria
Investigational Site Number :1120004
🇧🇾Vitebsk, Belarus
Investigational Site Number :1120005
🇧🇾Vitebsk, Belarus
Investigational Site Number : 0560009
🇧🇪Bruxelles, Belgium
Investigational Site Number :0560007
🇧🇪Bruxelles, Belgium
Investigational Site Number :0560003
🇧🇪Edegem, Belgium
Investigational Site Number : 0560004
🇧🇪Gent, Belgium
Investigational Site Number :0560006
🇧🇪Leuven, Belgium
Investigational Site Number :0560008
🇧🇪Liège, Belgium
Investigational Site Number :2030005
🇨🇿Praha 2, Czechia
Investigational Site Number :0560002
🇧🇪Mons, Belgium
Investigational Site Number :0560001
🇧🇪Pelt, Belgium
Investigational Site Number :1000002
🇧🇬Pleven, Bulgaria
Investigational Site Number :1000005
🇧🇬Plovdiv, Bulgaria
Investigational Site Number :1000004
🇧🇬Sofia, Bulgaria
Investigational Site Number :1000008
🇧🇬Sofia, Bulgaria
Investigational Site Number :1000001
🇧🇬Sofia, Bulgaria
Investigational Site Number :1000006
🇧🇬Sofia, Bulgaria
Investigational Site Number :1000009
🇧🇬Sofia, Bulgaria
Investigational Site Number :1240017
🇨🇦Burnaby, British Columbia, Canada
Investigational Site Number :1240011
🇨🇦Halifax, Nova Scotia, Canada
Investigational Site Number :1240003
🇨🇦Ottawa, Ontario, Canada
Investigational Site Number :1240008
🇨🇦Toronto, Ontario, Canada
Investigational Site Number :1240006
🇨🇦Gatineau, Quebec, Canada
Investigational Site Number :1240005
🇨🇦Greenfield Park, Quebec, Canada
Investigational Site Number :1240004
🇨🇦Montreal, Quebec, Canada
Investigational Site Number :1240015
🇨🇦Montreal, Quebec, Canada
Investigational Site Number :1240007
🇨🇦Sherbrooke, Quebec, Canada
Investigational Site Number : 1240001
🇨🇦Quebec, Canada
Investigational Site Number :1240021
🇨🇦Quebec, Canada
Investigational Site Number :1560006
🇨🇳Beijing, China
Investigational Site Number :1560012
🇨🇳Beijing, China
Investigational Site Number :1560021
🇨🇳Beijing, China
Investigational Site Number :1560003
🇨🇳Beijing, China
Investigational Site Number :1560009
🇨🇳Beijing, China
Investigational Site Number :1560004
🇨🇳Changchun, China
Investigational Site Number :1560015
🇨🇳Changsha, China
Investigational Site Number :1560005
🇨🇳Chengdu, China
Investigational Site Number :1560019
🇨🇳Chongqing, China
Investigational Site Number :1560035
🇨🇳Fuzhou, China
Investigational Site Number :2030010
🇨🇿Ostrava - Poruba, Czechia
Investigational Site Number :1560001
🇨🇳Guangzhou, China
Investigational Site Number :1560007
🇨🇳Hangzhou, China
Investigational Site Number :1560014
🇨🇳Shijiazhuang, China
Investigational Site Number :1560008
🇨🇳Taiyuan, China
Investigational Site Number :1560017
🇨🇳Xi'an, China
Investigational Site Number :2030002
🇨🇿Brno, Czechia
Investigational Site Number :2030004
🇨🇿Hradec Kralove, Czechia
Investigational Site Number :2030001
🇨🇿Jihlava, Czechia
Investigational Site Number :2030003
🇨🇿Teplice, Czechia
Investigational Site Number :2080001
🇩🇰Esbjerg, Denmark
Investigational Site Number :2080005
🇩🇰Holstebro, Denmark
Investigational Site Number :2080004
🇩🇰Odense, Denmark
Investigational Site Number :2460003
🇫🇮Helsinki, Finland
Investigational Site Number :2460001
🇫🇮Tampere, Finland
Investigational Site Number :2460002
🇫🇮Turku, Finland
Investigational Site Number :2500011
🇫🇷Bron, France
Investigational Site Number :2500005
🇫🇷Clermont Ferrand, France
Investigational Site Number :2500015
🇫🇷Gonesse, France
Investigational Site Number :2500009
🇫🇷Lille, France
Investigational Site Number :2500006
🇫🇷Montpellier, France
Investigational Site Number :2500008
🇫🇷Nancy, France
Investigational Site Number :2500010
🇫🇷Nantes, France
Investigational Site Number :2500017
🇫🇷Nimes, France
Investigational Site Number :2500016
🇫🇷Paris, France
Investigational Site Number :2500014
🇫🇷Paris, France
Investigational Site Number :2500007
🇫🇷Paris, France
Investigational Site Number :2500003
🇫🇷Rennes, France
Investigational Site Number :2500001
🇫🇷Strasbourg, France
Investigational Site Number :2500012
🇫🇷Toulouse, France
Investigational Site Number :2760005
🇩🇪Bayreuth, Germany
Investigational Site Number :2760009
🇩🇪Berlin, Germany
Investigational Site Number :2760001
🇩🇪Dresden, Germany
Investigational Site Number :2760012
🇩🇪Essen, Germany
Investigational Site Number :2760002
🇩🇪Gießen, Germany
Investigational Site Number :2760010
🇩🇪Halle (Saale), Germany
Investigational Site Number :2760006
🇩🇪Hannover, Germany
Investigational Site Number :2760008
🇩🇪Münster, Germany
Investigational Site Number :2760004
🇩🇪Rostock, Germany
Investigational Site Number :2760011
🇩🇪Ulm, Germany
Investigational Site Number :3000001
🇬🇷Athens, Greece
Investigational Site Number :3000006
🇬🇷Athens, Greece
Investigational Site Number :3000002
🇬🇷Athens, Greece
Investigational Site Number :3000007
🇬🇷Athens, Greece
Investigational Site Number :3000004
🇬🇷Larissa, Greece
Investigational Site Number :3000003
🇬🇷Thessaloniki, Greece
Investigational Site Number :3000005
🇬🇷Thessaloniki, Greece
Investigational Site Number :3480008
🇭🇺Budapest, Hungary
Investigational Site Number :3480004
🇭🇺Budapest, Hungary
Investigational Site Number :3480007
🇭🇺Budapest, Hungary
Investigational Site Number :3480002
🇭🇺Pécs, Hungary
Investigational Site Number :3480001
🇭🇺Szeged, Hungary
Investigational Site Number :3480006
🇭🇺Tatabánya, Hungary
Investigational Site Number :3560007
🇮🇳Gurgaon, India
Investigational Site Number :3560003
🇮🇳Gurgaon, India
Investigational Site Number :3560005
🇮🇳India, India
Investigational Site Number :3560004
🇮🇳Mangaluru, India
Investigational Site Number : 3560009
🇮🇳Nagpur, India
Investigational Site Number :3560006
🇮🇳New Delhi, India
Investigational Site Number :3560002
🇮🇳New Delhi, India
Investigational Site Number :3760002
🇮🇱Ashkelon, Israel
Investigational Site Number :3760003
🇮🇱Haifa, Israel
Investigational Site Number :3760008
🇮🇱Jerusalem, Israel
Investigational Site Number :3760001
🇮🇱Tel HaShomer, Israel
Investigational Site Number :3760004
🇮🇱Zefat, Israel
Investigational Site Number :3800011
🇮🇹Bergamo, Italy
Investigational Site Number :3800007
🇮🇹Cagliari, Italy
Investigational Site Number :3800012
🇮🇹Firenze, Italy
Investigational Site Number :3800016
🇮🇹Firenze, Italy
Investigational Site Number :3800014
🇮🇹Genova, Italy
Investigational Site Number :3800013
🇮🇹L'Aquila, Italy
Investigational Site Number :3800004
🇮🇹Milano, Italy
Investigational Site Number :3800001
🇮🇹Milano, Italy
Investigational Site Number :3800010
🇮🇹Milano, Italy
Investigational Site Number :3800008
🇮🇹Pavia, Italy
Investigational Site Number :3800005
🇮🇹Roma, Italy
Investigational Site Number :3800009
🇮🇹Roma, Italy
Investigational Site Number :3920016
🇯🇵Chiba-shi, Chiba, Japan
Investigational Site Number :3920022
🇯🇵Morioka-shi, Iwate, Japan
Investigational Site Number :3920011
🇯🇵Kyoto-shi, Kyoto, Japan
Investigational Site Number :3920020
🇯🇵Sendai-shi, Miyagi, Japan
Investigational Site Number :3920005
🇯🇵Niigata-shi, Niigata, Japan
Investigational Site Number :3920004
🇯🇵Moriguchi-shi, Osaka, Japan
Investigational Site Number :3920001
🇯🇵Osaka-shi, Osaka, Japan
Investigational Site Number :3920018
🇯🇵Kawagoe-shi, Saitama, Japan
Investigational Site Number :3920003
🇯🇵Kodaira-shi, Tokyo, Japan
Investigational Site Number :3920010
🇯🇵Ota-ku, Tokyo, Japan
Investigational Site Number :3920009
🇯🇵Ube-shi, Yamaguchi, Japan
Investigational Site Number :3920023
🇯🇵Sagamihara-shi, Japan
Investigational Site Number :4400003
🇱🇹Kaunas, Lithuania
Investigational Site Number :4400002
🇱🇹Klaipeda, Lithuania
Investigational Site Number :4400001
🇱🇹Vilnius, Lithuania
Investigational Site Number :5280001
🇳🇱Amsterdam, Netherlands
Investigational Site Number :5280003
🇳🇱Breda, Netherlands
Investigational Site Number :5280006
🇳🇱Groningen, Netherlands
Investigational Site Number :5280002
🇳🇱Sittard-Geleen, Netherlands
Investigational Site Number :5780003
🇳🇴Bergen, Norway
Investigational Site Number :5780002
🇳🇴Namsos, Norway
Investigational Site Number :5780001
🇳🇴Oslo, Norway
Investigational Site Number :6160003
🇵🇱Bydgoszcz, Kujawsko-pomorskie, Poland
Investigational Site Number :6160005
🇵🇱Warszawa, Mazowieckie, Poland
Investigational Site Number :6160006
🇵🇱Warszawa, Mazowieckie, Poland
Investigational Site Number :6160002
🇵🇱Katowice, Slaskie, Poland
Investigational Site Number :6160007
🇵🇱Katowice, Slaskie, Poland
Investigational Site Number :6160004
🇵🇱Katowice, Slaskie, Poland
Investigational Site Number :6420006
🇷🇴Cluj-Napoca, Romania
Investigational Site Number :6420003
🇷🇴Constanta, Romania
Investigational Site Number :6420013
🇷🇴Oradea, Romania
Investigational Site Number :6160008
🇵🇱Plewiska, Wielkopolskie, Poland
Investigational Site Number :6160001
🇵🇱Lodz, Poland
Investigational Site Number :6160012
🇵🇱Lublin, Poland
Investigational Site Number :6160011
🇵🇱Zabrze, Poland
Investigational Site Number :6200001
🇵🇹Braga, Portugal
Investigational Site Number :6200011
🇵🇹Lisboa, Portugal
Investigational Site Number :6200007
🇵🇹Lisboa, Portugal
Investigational Site Number :6200006
🇵🇹Lisboa, Portugal
Investigational Site Number :6200002
🇵🇹Matosinhos, Portugal
Investigational Site Number :6200010
🇵🇹Porto, Portugal
Investigational Site Number :6420008
🇷🇴Bucuresti, Romania
Investigational Site Number :6420004
🇷🇴Campulung, Romania
Investigational Site Number :6420005
🇷🇴Sibiu, Romania
Investigational Site Number :6420001
🇷🇴Targu Mures, Romania
Investigational Site Number :6420002
🇷🇴Timisoara, Romania
Investigational Site Number :6430018
🇷🇺Barnaul, Russian Federation
Investigational Site Number :6430023
🇷🇺Ekaterinburg, Russian Federation
Investigational Site Number :6430025
🇷🇺Kaliningrad, Russian Federation
Investigational Site Number :6430003
🇷🇺Kazan, Russian Federation
Investigational Site Number :6430022
🇷🇺Kemerovo, Russian Federation
Investigational Site Number :6430017
🇷🇺Kirov, Russian Federation
Investigational Site Number :6430024
🇷🇺Krasnoyarsk, Russian Federation
Investigational Site Number :6430020
🇷🇺Moscow, Russian Federation
Investigational Site Number :6430002
🇷🇺Moscow, Russian Federation
Investigational Site Number :6430013
🇷🇺Moscow, Russian Federation
Investigational Site Number :6430001
🇷🇺Moscow, Russian Federation
Investigational Site Number :6430008
🇷🇺Moscow, Russian Federation
Investigational Site Number :6430021
🇷🇺Nizhny Novgorod, Russian Federation
Investigational Site Number :6430006
🇷🇺Nizhny Novgorod, Russian Federation
Investigational Site Number :6430005
🇷🇺Novosibirsk, Russian Federation
Investigational Site Number :6430026
🇷🇺Perm, Russian Federation
Investigational Site Number :6430007
🇷🇺Pyatigorsk, Russian Federation
Investigational Site Number :6430016
🇷🇺Rostov-on-Don, Russian Federation
Investigational Site Number :6430004
🇷🇺Saint-Petersburg, Russian Federation
Investigational Site Number :6430009
🇷🇺Samara, Russian Federation
Investigational Site Number :6430019
🇷🇺Saransk, Russian Federation
Investigational Site Number :6430014
🇷🇺Smolensk, Russian Federation
Investigational Site Number :6430011
🇷🇺St-Petersburg, Russian Federation
Investigational Site Number :6430012
🇷🇺Tyumen, Russian Federation
Investigational Site Number :6430010
🇷🇺Ufa, Russian Federation
Investigational Site Number :7240007
🇪🇸Sevilla, Andalucia, Spain
Investigational Site Number :7240013
🇪🇸Barcelona, Barcelona [Barcelona], Spain
Investigational Site Number :8040007
🇺🇦Kharkiv, Ukraine
Investigational Site Number :7240016
🇪🇸Barcelona, Barcelona [Barcelona], Spain
Investigational Site Number :7240014
🇪🇸Salt, Girona [Gerona], Spain
Investigational Site Number :7240017
🇪🇸Las Palmas de Gran Canaria, Las Palmas, Spain
Investigational Site Number :7240004
🇪🇸Majadahonda, Madrid, Spain
Investigational Site Number :7240001
🇪🇸Pozuelo De Alarcón, Madrid, Spain
Investigational Site Number :7240012
🇪🇸Donostia, Pais Vasco, Spain
Investigational Site Number :7240008
🇪🇸Córdoba, Spain
Investigational Site Number :7240015
🇪🇸Lleida, Spain
Investigational Site Number :7240005
🇪🇸Madrid, Spain
Investigational Site Number :7240002
🇪🇸Madrid, Spain
Investigational Site Number :7240003
🇪🇸Madrid, Spain
Investigational Site Number :7240010
🇪🇸Murcia, Spain
Investigational Site Number :7240009
🇪🇸Málaga, Spain
Investigational Site Number :7240011
🇪🇸Valencia, Spain
Investigational Site Number :7920005
🇹🇷Eskisehir, Turkey
Investigational Site Number :7920010
🇹🇷Hatay, Turkey
Investigational Site Number :7920002
🇹🇷Istanbul, Turkey
Investigational Site Number :7920009
🇹🇷Istanbul, Turkey
Investigational Site Number :7920007
🇹🇷Istanbul, Turkey
Investigational Site Number :7920006
🇹🇷Istanbul, Turkey
Investigational Site Number :7920003
🇹🇷Istanbul, Turkey
Investigational Site Number :7920013
🇹🇷Izmir, Turkey
Investigational Site Number :7920001
🇹🇷Izmit, Turkey
Investigational Site Number :7920011
🇹🇷Kütahya, Turkey
Investigational Site Number :7920012
🇹🇷Mersin, Turkey
Investigational Site Number :7920008
🇹🇷Trabzon, Turkey
Investigational Site Number :8040008
🇺🇦Chernivtsi, Ukraine
Investigational Site Number :8040016
🇺🇦Chernivtsi, Ukraine
Investigational Site Number :8040003
🇺🇦Dnipro, Ukraine
Investigational Site Number :8040010
🇺🇦Ivano-Frankivsk, Ukraine
Investigational Site Number :8040011
🇺🇦Kharkiv, Ukraine
Investigational Site Number :8040012
🇺🇦Kharkiv, Ukraine
Investigational Site Number :8040013
🇺🇦Kyiv, Ukraine
Investigational Site Number :8040005
🇺🇦Lutsk, Ukraine
Investigational Site Number :8040009
🇺🇦Lviv, Ukraine
Investigational Site Number :8040004
🇺🇦Lviv, Ukraine
Investigational Site Number :8040002
🇺🇦Odesa, Ukraine
Investigational Site Number :8040006
🇺🇦Vinnytsia, Ukraine
Investigational Site Number :8040014
🇺🇦Zhytomyr, Ukraine
Investigational Site Number :8260003
🇬🇧Exeter, Devon, United Kingdom
Investigational Site Number :8260008
🇬🇧Plymouth, Devon, United Kingdom
Investigational Site Number :8260010
🇬🇧Swansea, Neath Port Talbot, United Kingdom
Investigational Site Number :8260012
🇬🇧Nottingham, Nottinghamshire, United Kingdom
Investigational Site Number :8260013
🇬🇧Oxford, Oxfordshire, United Kingdom
Investigational Site Number :8260009
🇬🇧Bristol, United Kingdom
Investigational Site Number :8260001
🇬🇧Cardiff, United Kingdom
Investigational Site Number :8260005
🇬🇧London, United Kingdom
Investigational Site Number :8260018
🇬🇧London, United Kingdom
Investigational Site Number :8260014
🇬🇧Newcastle Upon Tyne, United Kingdom
Investigational Site Number :8260019
🇬🇧Salford, United Kingdom