NL-OMON51591
Completed
Phase 4
Comprehensive Medical and Invasive Treatment strategy for patients with significant Left Anterior Descending artery disease - COMMIT-LAD
Zuyderland Medisch Centrum0 sites460 target enrollmentStarted: TBDLast updated:
Overview
- Phase
- Phase 4
- Status
- Completed
- Sponsor
- Zuyderland Medisch Centrum
- Enrollment
- 460
Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 18 to 99 (—)
Inclusion Criteria
- •Stable coronary artery disease OR
- •Hemodynamically stable patients with a Non\-STE Acute Coronary Syndrome AND
- •Hemodynamically significant LAD disease, as assessed by fractional flow reserve
- •(FFR, \<\= 0\.80\) measurements; OR \>90% lesion; OR non\-invasive evidence of ischemia.
- •Eligibility for complete revascularization (defined as a British Cardiovascular
- •Intervention Society \[BCIS] revascularisation index \>0\.8\). Please be aware that
- •in the case of a diffusely diseased LAD and randomisation for the percutaneous
- •arm, optimal medical therapy is seen as LAD\-revascularization.
- •The local Heart Team must conclude that:
- •The LAD, irrespective of focal or diffuse disease, is suitable for both
Exclusion Criteria
- •Previous CABG
- •Any target lesion with in\-stent restenosis within 1 year
- •Significant Left Main involvement
- •Significant valvular heart disease
- •Prior anterior myocardial infarction with clear evidence of residual akinesia
- •and/or dyskinesia
- •Extremely calcified or tortuous vessels precluding LAD FFR measurement or OCT
- •of the LAD.
- •Planned major surgery within the next 12 months
- •Extra\-cardiac illness that is expected to limit survival to less than 1 years
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