Evaluation of the effect of extract of nettle (Urtica Dioica) on blood glucose in adolescent patients with type 1 diabetes , A Randomized Double Blinded Controlled Trial

Phase 2

Conditions: Type 1 diabetes - insulin - children.
Insulin-dependent diabetes mellitus

Registration Number: IRCT20220516054879N2

Lead Sponsor: Rasht University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 50

Inclusion Criteria

12-18 years old Patients with type 1 diabetes treated with insulin
and with improper blood sugar control (A1C greater than 6.5 mg / dl)
provided that their BUN and serum creatinine are satisfactory and the patient does not classified as a patient with renal impairment.(BUN 8-20 mg / dL and creatinine less than 1.5 mg / dL.)

Exclusion Criteria

Patient reluctance
Patient taking lithium, warfarin and antihypertensive drugs Due to the existence of drug interactions according to the WHO source
History of previous allergies to nettle edible products
Change of more than 0.3 units in the parameters of patient's renal function

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Fasting blood glucose sugar reduction. Timepoint: The variable will be measured at the beginning of the study, 4, 8 and 12 weeks after the start of the study. Method of measurement: Home glucose testing devices or blood tests.

Secondary Outcome Measures

Name	Time	Method
A1C reduction. Timepoint: This variable will be measured at the beginning of the study and 12 weeks after the start of the study. Method of measurement: blood test.;Insulin dose reduction. Timepoint: This variable will be measured at the beginning of the study and 12 weeks after the start of the study. Method of measurement: blood test.