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Clinical Trials/NL-OMON42099
NL-OMON42099
Completed
Not Applicable

Visualizing beta cells in morbid obese patients with T2D before and after bariatric surgery - Visualizing beta cells before and after bariatric surgery

niversitair Medisch Centrum Sint Radboud0 sites12 target enrollmentTBD
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Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Not specified
Sponsor
niversitair Medisch Centrum Sint Radboud
Enrollment
12
Status
Completed
Last Updated
last year
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
TBD
Last Updated
last year
Study Type
Observational invasive

Investigators

Sponsor
niversitair Medisch Centrum Sint Radboud

Eligibility Criteria

Inclusion Criteria

  • •\- Morbid obese T2D patient who will undergone RYGB at the Rijnstate in Arnhem (BMI \> 35 kg/m2\)
  • •\- Signed informed consent;Mild T2D group
  • •o C\-peptide \> 1\.3 nmol/l
  • •o T2D diagnosis \< 2 years before RYGB
  • •o Only metformin usage as anti\-diabetic medication;Severe T2D group
  • •o C\-peptide \< 1 nmol/l
  • •o T2D diagnosis \> 4 years before RYGB
  • •o Insulin and/or sulfonylurea (SU) usage

Exclusion Criteria

  • •\- Fasting glucose \< 7 mmol/l at time C\-peptide was determined (Aarts et al. 2013\)
  • •\- Known liver failure or serum liver values over 2 times normal value at the time of standard laboratory assessment.
  • •\- BMI \> 50 kg/m2
  • •\- Previous treatment with synthetic Exendin (Exenatide, Byetta®) or Dipeptidyl\-Peptidase IV inhibitors
  • •\- Pregnancy or the wish to become pregnant within 18 months
  • •\- Breast feeding
  • •\- Kidney failure, i.e. calculated creatinine clearance below 40ml/min
  • •\- Age \<18 years
  • •\- No signed informed consent

Outcomes

Primary Outcomes

Not specified

Similar Trials

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Phase 1
Visualizing beta cells in morbid obese patients with T2D before and after bariatric surgery(NL51980.091.15)
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Visualizing beta cells in patients with remission of T2DM after bariatric surgeryPatients with Type 2 Diabetes, with or without remission after bariatric surgeryMedDRA version: 17.1Level: HLGTClassification code 10018424Term: Glucose metabolism disorders (incl diabetes mellitus)System Organ Class: 10014698 - Endocrine disordersMedDRA version: 17.1Level: HLTClassification code 10012602Term: Diabetes mellitus (incl subtypes)System Organ Class: 10014698 - Endocrine disordersMedDRA version: 17.1Level: PTClassification code 10012601Term: Diabetes mellitusSystem Organ Class: 10027433 - Metabolism and nutrition disordersTherapeutic area: Body processes [G] - Metabolic Phenomena [G03]
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