Determination of Drugs and Their Metabolites in Hospitalized Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Plasma concentrations [ng/mL] of various drugs at different timepoints
研究概览
简要总结
The current state of knowledge on the concentration of drugs and their metabolites in the individual human body is not satisfying concerning the question about behavior of drugs in the human body, taking into account individual patient factors such as age, weight and organ dysfunctions.
This projects deals with the question of drug levels in the blood of hospitalized patients.
The aim of this study is to extend the knowledge about the behavior of drugs in the human body significantly, for the safety and benefit of future patients. This also includes to establish a relationship between drug levels in patients and the desired and undesired effects of a drug.
As a result, the future perspective is to find the optimal dose for the individual patient by measuring the blood concentration of a drug.
详细描述
The primary goal of the study is to gain an overview of the plasma concentrations of relevant drugs which occur in different patient populations and to what extent they are consistent with those concentrations described in the literature.
If the expectation is confirmed, that a significant heterogeneity in the plasma concentrations of these patients exists, the investigators will try to find influencing factors for this circumstance on the basis of routine clinical parameters (height, weight, renal function, concomitant medications, etc.).
Ultimately, this project will identify substances with a high interindividual variability in plasma levels, where drug monitoring might be suggested.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •legal capacity
排除标准
- •severe anemia
结局指标
主要结局
Plasma concentrations [ng/mL] of various drugs at different timepoints
时间窗: up to five years
次要结局
未报告次要终点
研究者
Mr. Prof. Dr. Wilhelm
Prof. Dr. med. Martin Wilhelm
Klinikum Nürnberg